Articles with "permeation enhancer" as a keyword



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Progress and limitations of oral peptide delivery as a potentially transformative therapy

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Published in 2022 at "Expert Opinion on Drug Delivery"

DOI: 10.1080/17425247.2022.2051476

Abstract: ABSTRACT Introduction Numerous formulation technologies have been developed to overcome challenges of oral peptide delivery. Understanding the advantages and limitations of each technology is important for the development of new delivery systems to enable oral… read more here.

Keywords: peptide delivery; oral peptide; permeation enhancer; delivery ... See more keywords
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Structure–activity relationship of a peptide permeation enhancer

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Published in 2022 at "Tissue Barriers"

DOI: 10.1080/21688370.2022.2060692

Abstract: ABSTRACT The pentapeptide L-R5 has previously been shown to transiently increase the permeability of nasal epithelial cell layers in vitro, allowing paracellular transport of molecules of up to 4 kDa. Protein kinase C zeta (PKC… read more here.

Keywords: structure activity; activity relationship; activity; permeation enhancer ... See more keywords
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Impact of Insulin Tregopil and Its Permeation Enhancer on Pharmacokinetics of Metformin in Healthy Volunteers: Randomized, Open‐Label, Placebo‐Controlled, Crossover Study

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Published in 2019 at "Clinical and Translational Science"

DOI: 10.1111/cts.12609

Abstract: Oral insulin tregopil (IN‐105; a new drug under development) may be coadministered with oral antidiabetic drugs, such as metformin in patients with type 2 diabetes mellitus for optimal glycemic control. IN‐105 has sodium caprate excipient,… read more here.

Keywords: randomized open; permeation enhancer; study; healthy volunteers ... See more keywords