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Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2051476
Abstract: ABSTRACT Introduction Numerous formulation technologies have been developed to overcome challenges of oral peptide delivery. Understanding the advantages and limitations of each technology is important for the development of new delivery systems to enable oral…
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Keywords:
peptide delivery;
oral peptide;
permeation enhancer;
delivery ... See more keywords
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Published in 2022 at "Tissue Barriers"
DOI: 10.1080/21688370.2022.2060692
Abstract: ABSTRACT The pentapeptide L-R5 has previously been shown to transiently increase the permeability of nasal epithelial cell layers in vitro, allowing paracellular transport of molecules of up to 4 kDa. Protein kinase C zeta (PKC…
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Keywords:
structure activity;
activity relationship;
activity;
permeation enhancer ... See more keywords
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Published in 2019 at "Clinical and Translational Science"
DOI: 10.1111/cts.12609
Abstract: Oral insulin tregopil (IN‐105; a new drug under development) may be coadministered with oral antidiabetic drugs, such as metformin in patients with type 2 diabetes mellitus for optimal glycemic control. IN‐105 has sodium caprate excipient,…
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Keywords:
randomized open;
permeation enhancer;
study;
healthy volunteers ... See more keywords