An evaluation of crude palm oil (CPO) and tocotrienol rich fraction (TRF) of palm oil as percutaneous permeation enhancers using full-thickness human skin
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2018.1509347
Abstract: Abstract The drawbacks associated with chemical skin permeation enhancers such as skin irritation and toxicity necessitated the research to focus on potential permeation enhancers with a perceived lower toxicity. Crude palm oil (CPO) is obtained… read more here.
Keywords: cpo; permeation enhancers; palm oil; human skin ... See more keywords
Evaluations of imidazolium ionic liquids as novel skin permeation enhancers for drug transdermal delivery
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Development and Technology"
DOI: 10.3109/10837450.2015.1131718
Abstract: Abstract In this work, imidazolium ionic liquids (imidazolium ILs) were employed as the novel chemical permeation enhancers (CPEs) and their performances and mechanisms of action were deeply investigated. Testosterone was used as a model drug… read more here.
Keywords: permeation enhancers; permeation; delivery; drug ... See more keywords
Gastrointestinal Permeation Enhancers for the Development of Oral Peptide Pharmaceuticals
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15121585
Abstract: Recently, two oral-administered peptide pharmaceuticals, semaglutide and octreotide, have been developed and are considered as a breakthrough in peptide and protein drug delivery system development. In 2019, the Food and Drug Administration (FDA) approved an… read more here.
Keywords: oral peptide; development; gastrointestinal permeation; permeation ... See more keywords
New Insights on the Mechanism of Fatty Acids as Buccal Permeation Enhancers
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DOI: 10.3390/pharmaceutics10040201
Abstract: Buccal mucosa has recently received much attention as a potential route for systemic delivery of drugs, including biologics and vaccines. The aim of this work was to gain insight into the mechanism of fatty acids… read more here.
Keywords: permeation enhancers; buccal permeation; mechanism fatty; fatty acids ... See more keywords
Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
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DOI: 10.3390/pharmaceutics12030242
Abstract: Sufficient colonic absorption is necessary for all systemically acting drugs in dosage forms that release the drug in the large intestine. Preclinically, colonic absorption is often investigated using the rat single-pass intestinal perfusion model. This… read more here.
Keywords: permeation enhancers; regional intestinal; drug permeability; permeability ... See more keywords
Improvement of Resveratrol Permeation through Sublingual Mucosa: Chemical Permeation Enhancers versus Spray Drying Technique to Obtain Fast-Disintegrating Sublingual Mini-Tablets
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13091370
Abstract: Resveratrol (RSV) is a natural polyphenol with several interesting broad-spectrum pharmacological properties. However, it is characterized by poor oral bioavailability, extensive first-pass effect metabolism and low stability. Indeed, RSV could benefit from the advantage of… read more here.
Keywords: permeation enhancers; sublingual mucosa; fast disintegrating; mini tablets ... See more keywords
Inulin-Based Polymeric Micelles Functionalized with Ocular Permeation Enhancers: Improvement of Dexamethasone Permeation/Penetration through Bovine Corneas
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DOI: 10.3390/pharmaceutics13091431
Abstract: Ophthalmic drug delivery is still a challenge due to the protective barriers of the eye. A common strategy to promote drug absorption is the use of ocular permeation enhancers, while an innovative approach is the… read more here.
Keywords: inulin based; permeation enhancers; permeation; ocular permeation ... See more keywords
N-Alkylmorpholines: Potent Dermal and Transdermal Skin Permeation Enhancers
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DOI: 10.3390/pharmaceutics14010064
Abstract: Transdermal drug delivery is an attractive non-invasive method offering numerous advantages over the conventional routes of administration. The main obstacle to drug transport is, however, the powerful skin barrier that needs to be modulated, for… read more here.
Keywords: permeation; potent dermal; dermal transdermal; toxicity ... See more keywords
Improved Topical Drug Delivery: Role of Permeation Enhancers and Advanced Approaches
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DOI: 10.3390/pharmaceutics14122818
Abstract: The delivery of drugs via transdermal routes is an attractive approach due to ease of administration, bypassing of the first-pass metabolism, and the large skin surface area. However, a major drawback is an inability to… read more here.
Keywords: improved topical; drug delivery; drug; delivery ... See more keywords
Effect of Polymers and Permeation Enhancers in the Release of Quetiapine Fumarate Transdermal Patch through the Dialysis Membrane
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DOI: 10.3390/polym14101984
Abstract: Quetiapine Fumarate is potent, and the daily therapeutic dose can be delivered easily across the skin with the help of permeation enhancers. Quetiapine Fumarate-loaded transdermal patches were prepared by solvent evaporation technique. Various formulation parameters,… read more here.
Keywords: fumarate transdermal; quetiapine fumarate; transdermal patch; fumarate ... See more keywords