A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Cell stem cell"
DOI: 10.1016/j.stem.2019.06.008
Abstract: Following injury, differentiated epithelial cells can serve as a stem cell-independent source for tissue regeneration by undergoing reprogramming into other cell types. The intrinsic molecular basis underlying plasticity of differentiated cells remains largely unaddressed. Here… read more here.
Keywords: chromatin state; regeneration; liver injury; permissive chromatin ... See more keywords
Structural Variation Cooperates with Permissive Chromatin to Control Enhancer Hijacking-Mediated Oncogenic Transcription.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood-2022-169565
Abstract: Structural variants (SVs) involving enhancer hijacking can rewire chromatin topologies to cause oncogene activation in human cancers including hematologic malignancies; however, due to the lack of tools to assess their effects on gene regulation and… read more here.
Keywords: transcription; enhancer hijacking; chromatin; structural variation ... See more keywords