Abundance of DNA adducts of 4-oxo-2-alkenals, lipid peroxidation-derived highly reactive genotoxins
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.17-90
Abstract: Reactive oxygen species and their reaction products can damage DNA to form mutagenic lesions. Among the reactive species, lipid peroxidation-derived aldehydes react with nucleobases and form bulky exocyclic adducts. Many types of aldehyde-derived DNA adducts… read more here.
Keywords: oxo alkenals; dna adducts; peroxidation derived; lipid peroxidation ... See more keywords
The lipid peroxidation derived DNA adduct γ-OHPdG levels in paraneoplastic liver tissues predict postoperative outcomes of hepatoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer"
DOI: 10.7150/jca.56982
Abstract: Chronic necroinflammation in liver induces lipid peroxidation and oxidative stress, which contributes to hepatocellular carcinoma (HCC) development. Gamma-hydroxy-1, N2-propanodeoxyguanosine (γ-OHPdG), a promutagenic DNA adduct, is derived from lipid peroxidation. Little is known about the clinical… read more here.
Keywords: lipid peroxidation; dna adduct; peroxidation; peroxidation derived ... See more keywords