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   Articles with "peroxiredoxin" as a keyword



Peroxiredoxin 1 transfer during mating protects eupyrene sperm against oxdative stress in Grapholita molesta.

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recommendations! Published in 2023 at "Pest management science"

DOI: 10.1002/ps.7458

Abstract: BACKGROUND Each Grapholita molesta female only copulates once during its lifetime and thus must maintain the viability of stored eupyrene sperm for male reproductive success. The male ejaculate comprises abundant accessory gland proteins produced by… read more here.

Keywords: eupyrene sperm; stress; peroxiredoxin; grapholita molesta ... See more keywords
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Screening compound libraries for H2O2-mediated cancer therapeutics using a peroxiredoxin-based sensor.

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recommendations! Published in 2021 at "Cell chemical biology"

DOI: 10.1016/j.chembiol.2021.09.003

Abstract: Compounds that modulate H2O2 reaction networks have applications as targeted cancer therapeutics, as a subset of cancers exhibit sensitivity to this redox signal. Previous studies to identify therapeutics that induce oxidants have relied upon probes… read more here.

Keywords: peroxiredoxin; h2o2 mediated; screening compound; cancer therapeutics ... See more keywords

Oxidation state of peroxiredoxin 4 in lungs from patients with pulmonary fibrosis and mouse models of fibrosis

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.10.014

Abstract: Rationale Every year 34,000 people in the United States are diagnosed with Idiopathic Pulmonary Fibrosis (IPF). The average survival time for these patients is only 3-5 years after diagnosis. Recently we have shown that the… read more here.

Keywords: mouse models; fibrosis; prdx4; peroxiredoxin ... See more keywords

'Candidatus Liberibacter asiaticus' peroxiredoxin (LasBCP) suppresses oxylipin-mediated defense signaling in citrus.

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recommendations! Published in 2019 at "Journal of plant physiology"

DOI: 10.1016/j.jplph.2019.03.001

Abstract: The Lasbcp (CLIBASIA_RS00445) 1-Cys peroxiredoxin gene is conserved among all 13 sequenced strains of Candidatus Liberibacter asiaticus, the causal agent of Huanglongbing or "citrus greening" disease. LasBCP was previously characterized as a secreted peroxiredoxin with… read more here.

Keywords: peroxiredoxin; lasbcp; candidatus liberibacter; liberibacter asiaticus ... See more keywords

Peroxiredoxin 4 as a switch regulating PTEN/AKT axis in alveolar macrophages activation

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recommendations! Published in 2025 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-025-02454-x

Abstract: Phosphatase and tensin homolog (PTEN) is a critical inhibitor of the PI3K/AKT signaling pathway, yet its direct upstream regulators remain poorly defined. In this study, we investigated the role of peroxiredoxin 4 (PRDX4) in alveolar… read more here.

Keywords: fibrosis; switch regulating; peroxiredoxin; alveolar macrophages ... See more keywords

ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5

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recommendations! Published in 2019 at "Nature chemical biology"

DOI: 10.1038/s41589-019-0399-y

Abstract: S-palmitoylation is a reversible lipid post-translational modification that has been observed on mitochondrial proteins, but both the regulation and functional consequences of mitochondrial S-palmitoylation are poorly understood. Here, we show that perturbing the “erasers” of… read more here.

Keywords: palmitoylation; abhd10 depalmitoylase; peroxiredoxin; depalmitoylase affecting ... See more keywords

Inflammation-induced reactive nitrogen species cause proteasomal degradation of dimeric peroxiredoxin-1 in a mouse macrophage cell line

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recommendations! Published in 2019 at "Free Radical Research"

DOI: 10.1080/10715762.2019.1637863

Abstract: Abstract Peroxiredoxin 1 (PRDX1) is an antioxidant enzyme that, when secreted, can act as a proinflammatory signal. Here we studied the regulation of intracellular PRDX1 by lipopolysaccharide (LPS) and interferon-gamma (IFN-γ) in the RAW 264.7… read more here.

Keywords: cell line; macrophage cell; peroxiredoxin; mouse macrophage ... See more keywords

The effects of Fasciola hepatica recombinant proteins (peroxiredoxin and cathepsin L1) on Crohn's disease experimental model

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recommendations! Published in 2024 at "Parasite Immunology"

DOI: 10.1111/pim.13019

Abstract: The immunomodulatory potential of the excretory‐secretory (E/S) proteins of the helminths has been shown in previous investigations. This study evaluated the effects of the recombinants and excretory‐secretory proteins of the Fasciola hepatica on induced colitis… read more here.

Keywords: fasciola hepatica; peroxiredoxin; hepatica; hepatica recombinant ... See more keywords

Mitochondrion-associated protein peroxiredoxin 3 promotes benign prostatic hyperplasia through autophagy suppression and pyroptosis activation.

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.17927

Abstract: Benign prostatic hyperplasia (BPH) is one of the most common diseases in the senior men and age plays an important role in the initiation and development of BPH. Mammalian cells primarily use the autophagy-lysosome system… read more here.

Keywords: epithelial cells; pyroptosis; benign prostatic; peroxiredoxin ... See more keywords

AMRI-59 functions as a radiosensitizer via peroxiredoxin I-targeted ROS accumulation and apoptotic cell death induction

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.23114

Abstract: Previously, we identified AMRI-59 as a specific pharmaceutical inhibitor of peroxiredoxin (PRX) I enzyme activity. In this study, we examined whether AMRI-59 acts as a radiosensitizer in non-small cell lung cancer cells using clonogenic assays.… read more here.

Keywords: amri; peroxiredoxin; amri functions; cell death ... See more keywords

Ainsliadimer A induces ROS-mediated apoptosis in colorectal cancer cells via directly targeting peroxiredoxin 1 and 2.

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recommendations! Published in 2023 at "Cell chemical biology"

DOI: 10.2139/ssrn.4090936

Abstract: The peroxiredoxin (PRDX) family is a class of antioxidant enzymes with peroxidase activity. Human PRDXs currently have six members (PRDX1-6), which are gradually becoming potential therapeutic targets for major diseases such as cancer. In this… read more here.

Keywords: cancer; peroxiredoxin; colorectal cancer; ainsliadimer induces ... See more keywords