Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma 2 may be associated with adverse neurodevelopment in European preterm babies
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2256
Abstract: Prematurity is the leading cause of death and disability in children under 5 years of age. Understanding the molecular mechanisms of the biological processes involved in preterm brain injury may help develop novel neuroprotective treatment… read more here.
Keywords: peroxisome proliferator; preterm babies; proliferator activated; activated receptor ... See more keywords
Keratin 23 Is a Peroxisome Proliferator‐Activated Receptor Alpha–Dependent, MYC‐Amplified Oncogene That Promotes Hepatocyte Proliferation
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30530
Abstract: Chronic activation of the nuclear receptor peroxisome proliferator–activated receptor alpha (PPARA) promotes MYC‐linked hepatocellular carcinoma (HCC) in mice. Recent studies have shown that MYC can function as an amplifier of transcription where MYC does not… read more here.
Keywords: peroxisome proliferator; ppara; proliferation; expression ... See more keywords
In vitro and in silico analyses of Vicia faba L. on Peroxisome proliferator–activated receptor gamma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27123
Abstract: The agonists of peroxisome proliferator–activated receptor gamma (PPARγ) from natural victual products were used as antidiabetic agents. Faba bean (Vicia faba L.) is a consequential legume that was known to possess potential antidiabetic activity, whose… read more here.
Keywords: peroxisome proliferator; faba bean; proliferator activated; activated receptor ... See more keywords
The role of various peroxisome proliferator‐activated receptors and their ligands in clinical practice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25804
Abstract: Peroxisome proliferator‐activated receptors (PPARs) are ligand‐activated transcription factors involved in several physiological processes including modulation of cellular differentiation, development, metabolism of carbohydrates, lipids, proteins, and tumorigenesis. The aim of this review is to examine how… read more here.
Keywords: peroxisome proliferator; ppar ligands; proliferator activated; clinical practice ... See more keywords
Regulatory mechanisms mediated by peroxisome proliferator‐activated receptor‐β/δ in skin cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23033
Abstract: Considerable progress has been made during the past 20 years towards elucidating the role of peroxisome proliferator‐activated receptor‐β/δ (PPARβ/δ) in skin cancer. In 1999, the original notion that PPARβ/δ was involved with epithelial cell function… read more here.
Keywords: ppar; peroxisome proliferator; proliferator activated; skin cancer ... See more keywords
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator-activated receptor α agonists in cardiovascular health and disease.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21970
Abstract: The prevalence of cardiovascular disease (CVD) has been rising due to sedentary lifestyles and unhealthy dietary patterns. Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor regulating multiple biological processes, such as lipid metabolism and… read more here.
Keywords: inflammation; peroxisome proliferator; ppar; proliferator activated ... See more keywords
Proteomics coupled transcriptomics reveals lipopolysaccharide inhibiting peroxisome proliferator-activated receptors signalling pathway to reduce lipid droplets accumulation in mouse liver.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202300043
Abstract: Lipid droplets (LDs) are multifunctional organelles consisting of a central compartment of non-polar lipids shielded from the cytoplasm by a phospholipid monolayer. The excessive accumulation of LDs in cells is closely related to the development… read more here.
Keywords: peroxisome proliferator; proliferator activated; lipid droplets; mouse liver ... See more keywords
Understanding Peroxisome Proliferator-Activated Receptors: From the Structure to the Regulatory Actions on Metabolism.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-11488-6_3
Abstract: Peroxisome proliferator-activated receptors (PPARs) are multi-domains proteins, belonging to the superfamily of nuclear receptors, which mainly act as ligand-activated transcription factors. A variety of lipophilic molecules, including long-chain polyunsaturated fatty acids and eicosanoids, are capable… read more here.
Keywords: peroxisome proliferator; metabolism; proliferator activated; activated receptors ... See more keywords
Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation Research"
DOI: 10.1007/s00011-019-01231-1
Abstract: The peroxisome proliferator-activated receptor (PPAR) family includes three transcription factors: PPARα, PPARβ/δ, and PPARγ. PPAR are nuclear receptors activated by oxidised and nitrated fatty acid derivatives as well as by cyclopentenone prostaglandins (PGA2 and 15d-PGJ2)… read more here.
Keywords: ppar; peroxisome proliferator; proliferator activated; inflammatory response ... See more keywords
Structure-based design, synthesis, PPAR-γ activation, and molecular docking of N-substituted phthalimides
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1867-0
Abstract: N-substituted phthalimides showed peroxisome proliferator-activated receptors-γ activation in rat liver epithelial Ac2F cells in our previous study. In order to explore better peroxisome proliferator-activated receptors-γ agonists, new N-substituted phthalimide derivatives were designed and synthesized based… read more here.
Keywords: peroxisome proliferator; substituted phthalimides; proliferator activated; activated receptors ... See more keywords
Integrated in silico–in vitro screening of ovarian cancer peroxisome proliferator-activated receptor-γ agonists against a biogenic compound library
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2060-1
Abstract: In recent years, peroxisome proliferator-activated receptor-γ (PPARγ) activation by selective agonists has been emerged as a new and promising strategy for ovarian cancer therapy and prevention. Here, an integrated screening protocol that combined computational protein–ligand… read more here.
Keywords: peroxisome proliferator; activated receptor; proliferator activated; ovarian cancer ... See more keywords