Persistent Immune Stimulation Exacerbates Genetically Driven Myeloproliferative Disorders via Stromal Remodeling.
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DOI: 10.1158/0008-5472.can-17-1098
Abstract: Systemic immune stimulation has been associated with increased risk of myeloid malignancies, but the pathogenic link is unknown. We demonstrate in animal models that experimental systemic immune activation alters the bone marrow stromal microenvironment, disarranging… read more here.
Keywords: persistent immune; exacerbates genetically; stimulation; stimulation exacerbates ... See more keywords