Identification of N‐Arylated NH125 Analogues as Rapid Eradicating Agents against MRSA Persister Cells and Potent Biofilm Killers of Gram‐Positive Pathogens
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DOI: 10.1002/cbic.201600622
Abstract: Bacterial biofilms housing dormant persister cells are innately tolerant to antibiotics and disinfectants, yet several membrane‐active agents are known to eradicate tolerant bacterial cells. NH125, a membrane‐active persister killer and starting point for development, led… read more here.
Keywords: agents mrsa; membrane active; persister cells; persister ... See more keywords
Ribosome dependence of persister cell formation and resuscitation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Microbiology"
DOI: 10.1007/s12275-019-8629-2
Abstract: Since most bacterial cells are starving, they must enter a resting stage. Persister is the term used for metabolically-dormant cells that are not spores, and these cells arise from stress such as that from antibiotics… read more here.
Keywords: ribosome dependence; persister; formation resuscitation; persister cells ... See more keywords
Evaluation of gene expression and protein structural modeling involved in persister cell formation in Salmonella Typhimurium
Sign Up to like & getrecommendations! Published in 2020 at "Brazilian Journal of Microbiology"
DOI: 10.1007/s42770-020-00388-w
Abstract: Persisters are phenotypic variants of the bacterial population that survive against lethal doses of bactericidal antibiotics.These phenotypes are created in numerous bacterial species, including those of clinical significance, such as Salmonella Typhimurium. Since persister cells… read more here.
Keywords: cell formation; persister cells; persister; formation ... See more keywords
SmpB down-regulates proton-motive force for the persister tolerance to aminoglycosides in Aeromonas veronii.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.11.052
Abstract: Bacterial persisters comprise a small fraction of phenotypically heterogeneous variants with transient capability for survival when exposed to high concentrations of antibiotic. In aquatic pathogenic bacteria Aeromonas veronii, Small Protein B (SmpB), the core factor… read more here.
Keywords: smpb regulates; motive force; persister; proton motive ... See more keywords
Ploidy is an important determinant of fluoroquinolone persister survival
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DOI: 10.1016/j.cub.2021.02.040
Abstract: Genetic mutants have demonstrated the importance of homologous recombination (HR) to fluoroquinolone (FQ) persistence, which suggests that single-cell chromosome (Chr) abundance might be a phenotypic variable of importance to persisters. Here, we sorted stationary-phase E. coli… read more here.
Keywords: important determinant; persister; ploidy important; enriched subpopulations ... See more keywords
Identification and validation of reference genes for reliable analysis of differential gene expression during antibiotic induced persister formation in Klebsiella pneumoniae using qPCR.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of microbiological methods"
DOI: 10.1016/j.mimet.2021.106165
Abstract: The study of differential gene expression in persister cells is compounded by ceasure of conventional cellular metabolic pathways during persistence. There is, hence, a requirement to identify and validate suitable reference genes whose expression remains… read more here.
Keywords: differential gene; persister; gene expression; formation ... See more keywords
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
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DOI: 10.1038/nature24297
Abstract: Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer ‘persister’ cells. The persister cell pool… read more here.
Keywords: drug resistance; persister cells; persister; drug ... See more keywords
Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection
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DOI: 10.1038/s41467-018-04472-6
Abstract: Non-typhoidal Salmonella strains are responsible for invasive infections associated with high mortality and recurrence in sub-Saharan Africa, and there is strong evidence for clonal relapse following antibiotic treatment. Persisters are non-growing bacteria that are thought… read more here.
Keywords: persister formation; acetyltransferase toxins; salmonella persister; persister ... See more keywords
An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
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DOI: 10.1038/s41467-019-13360-6
Abstract: Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAFV600 mutant melanoma cells that tolerates exposure to BRAF and MEK… read more here.
Keywords: melanoma; persister cells; persister; mrna translation ... See more keywords
Cycling cancer persister cells arise from lineages with distinct programs.
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DOI: 10.1038/s41586-021-03796-6
Abstract: Non-genetic mechanisms have recently emerged as important drivers of cancer therapy failure1, where some cancer cells can enter a reversible drug-tolerant persister state in response to treatment2. Although most cancer persisters remain arrested in the… read more here.
Keywords: cycling cancer; lineages distinct; persister; cycling persisters ... See more keywords
Gold nanocluster adjuvant enables the eradication of persister cells by antibiotics and abolishes the emergence of resistance.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr01003h
Abstract: Persister cells are responsible for relapses of infections common in cystic fibrosis and chronic suppurative otitis media (CSOM). Yet, there are no Food and Drug Administration (FDA) approved antibiotics to eradicate persister cells. Frustratingly, the… read more here.
Keywords: aunc cpp; persister cells; resistance; persister ... See more keywords