Identification of N‐Arylated NH125 Analogues as Rapid Eradicating Agents against MRSA Persister Cells and Potent Biofilm Killers of Gram‐Positive Pathogens
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DOI: 10.1002/cbic.201600622
Abstract: Bacterial biofilms housing dormant persister cells are innately tolerant to antibiotics and disinfectants, yet several membrane‐active agents are known to eradicate tolerant bacterial cells. NH125, a membrane‐active persister killer and starting point for development, led… read more here.
Keywords: agents mrsa; membrane active; persister cells; persister ... See more keywords
Studying Bacterial Persistence: Established Methods and Current Advances.
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DOI: 10.1007/978-1-0716-1621-5_1
Abstract: To date, we are living in a postantibiotic era in which several human pathogens have developed multidrug resistance and very few new antibiotics are being discovered. In addition to the problem of antibiotic resistance, every… read more here.
Keywords: established methods; studying bacterial; persister cells; persistence ... See more keywords
Enrichment of Persister Cells Through Β-Lactam-Induced Filamentation and Size Separation.
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DOI: 10.1007/978-1-0716-1621-5_4
Abstract: Analyzing persisters at the single-cell level is crucial to properly define their phenotypic traits. However, single-cell analyses are challenging due to the rare and temporary nature of persister cells, thus requiring their rapid and efficient… read more here.
Keywords: persister cells; induced filamentation; cell; lactam induced ... See more keywords
Ribosome dependence of persister cell formation and resuscitation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Microbiology"
DOI: 10.1007/s12275-019-8629-2
Abstract: Since most bacterial cells are starving, they must enter a resting stage. Persister is the term used for metabolically-dormant cells that are not spores, and these cells arise from stress such as that from antibiotics… read more here.
Keywords: ribosome dependence; persister; formation resuscitation; persister cells ... See more keywords
Evaluation of gene expression and protein structural modeling involved in persister cell formation in Salmonella Typhimurium
Sign Up to like & getrecommendations! Published in 2020 at "Brazilian Journal of Microbiology"
DOI: 10.1007/s42770-020-00388-w
Abstract: Persisters are phenotypic variants of the bacterial population that survive against lethal doses of bactericidal antibiotics.These phenotypes are created in numerous bacterial species, including those of clinical significance, such as Salmonella Typhimurium. Since persister cells… read more here.
Keywords: cell formation; persister cells; persister; formation ... See more keywords
Bacteriophage Sb-1 enhances antibiotic activity against biofilm, degrades exopolysaccharide matrix and targets persisters of Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.09.006
Abstract: Most antibiotics have limited or no activity against bacterial biofilms, whereas bacteriophages can eradicate biofilms. We evaluated whether Staphylococcus aureus-specific bacteriophage Sb-1 could eradicate biofilm, both alone and in combination with different classes of antibiotics,… read more here.
Keywords: staphylococcus aureus; persister cells; bacteriophage; biofilm ... See more keywords
Stabbed while Sleeping: Synthetic Retinoid Antibiotics Kill Bacterial Persister Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.05.029
Abstract: Antibiotic-tolerant persister cells are difficult to eradicate by conventional classes of antibiotics. Kim and colleagues have discovered a new class of synthetic retinoid antibiotics that kill Staphylococcus aureus persisters by disrupting their cytoplasmic membrane. read more here.
Keywords: synthetic retinoid; retinoid antibiotics; persister cells; antibiotics kill ... See more keywords
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
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DOI: 10.1038/nature24297
Abstract: Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer ‘persister’ cells. The persister cell pool… read more here.
Keywords: drug resistance; persister cells; persister; drug ... See more keywords
An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
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DOI: 10.1038/s41467-019-13360-6
Abstract: Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAFV600 mutant melanoma cells that tolerates exposure to BRAF and MEK… read more here.
Keywords: melanoma; persister cells; persister; mrna translation ... See more keywords
Gold nanocluster adjuvant enables the eradication of persister cells by antibiotics and abolishes the emergence of resistance.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr01003h
Abstract: Persister cells are responsible for relapses of infections common in cystic fibrosis and chronic suppurative otitis media (CSOM). Yet, there are no Food and Drug Administration (FDA) approved antibiotics to eradicate persister cells. Frustratingly, the… read more here.
Keywords: aunc cpp; persister cells; resistance; persister ... See more keywords
Persister Cells Resuscitate via Ribosome Modification by 23S rRNA Pseudouridine Synthase RluD.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental microbiology"
DOI: 10.1111/1462-2920.14828
Abstract: Upon a wide range of stress conditions (e.g., nutrient, antibiotic, oxidative), a subpopulation of bacterial cells known as persisters survive by halting metabolism. These cells resuscitate rapidly to reconstitute infections once the stress is removed… read more here.
Keywords: persister cells; rrna pseudouridine; cells resuscitate; rlud ... See more keywords