Pharmacogenetic testing for NAT2 genotypes in a Tanzanian population across the lifespan to guide future personalized isoniazid dosing.
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DOI: 10.2139/ssrn.4087384
Abstract: Despite updated recommendations for weight-based isoniazid dosing in children with drug-susceptible tuberculosis (TB) and higher dose isoniazid in regimens for adults with drug-resistant TB, individual pharmacokinetic variability can lead to sub-target isoniazid exposure. Host pharmacogenetics… read more here.
Keywords: pharmacogenetic testing; personalized isoniazid; guide; isoniazid dosing ... See more keywords