Metabolic Subtyping for Novel Personalized Therapies Against Pancreatic Cancer
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DOI: 10.1158/1078-0432.ccr-19-2926
Abstract: Through metabolic subtyping, metabolic vulnerabilities can be exploited for developing efficacious treatments. A glycolytic subtype indicates poor survival in patients with pancreatic cancer, whereas a cholesterogenic subtype correlates with better outcomes potentially due to more… read more here.
Keywords: metabolic subtyping; novel personalized; cancer; personalized therapies ... See more keywords
First Steps toward Personalized Therapies for ABCA3 Deficiency
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2021-0405ed
Abstract: The ABCA3 (ATP-binding cassette transporter A3) protein transports phospholipids from the cytoplasm into lamellar bodies in alveolar type II cells (AEC2s) and is critical for pulmonary surfactant synthesis and function. Biallelic pathogenic ABCA3 variants cause… read more here.
Keywords: first steps; steps toward; therapies abca3; toward personalized ... See more keywords
The Road to Personalized Therapies: Lessons Learned From Angelman Syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "American journal on intellectual and developmental disabilities"
DOI: 10.1352/1944-7558-127.2.95
Abstract: Angelman syndrome (AS) is a neurogenetic disorder characterized by delays including a severe expressive language delay, motor concerns, ataxia, epilepsy, sleep disturbances, gastrointestinal problems, and characteristic behaviors, including a happy demeanor, hyperactivity, and excitability. The… read more here.
Keywords: road; road personalized; lessons learned; personalized therapies ... See more keywords
Drosophila melanogaster: A platform for anticancer drug discovery and personalized therapies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.949241
Abstract: Cancer is a complex disease whereby multiple genetic aberrations, epigenetic modifications, metabolic reprogramming, and the microenvironment contribute to the development of a tumor. In the traditional anticancer drug discovery pipeline, drug candidates are usually screened… read more here.
Keywords: drug discovery; anticancer drug; personalized therapies; drug ... See more keywords
Metabolomic and Lipidomic Profiling of Gliomas—A New Direction in Personalized Therapies
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DOI: 10.3390/cancers14205041
Abstract: Simple Summary Gliomas comprise an extremely diverse category of brain tumors that are difficult to diagnose and treat. As a result, scientists continue to search for new treatment solutions, with personalized medicine having emerged as… read more here.
Keywords: lipidomic profiling; personalized therapies; gliomas new; treatment ... See more keywords
Natural Bacterial and Fungal Peptides as a Promising Treatment to Defeat Lung Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28114381
Abstract: Despite the increasing availability of modern treatments, including personalized therapies, there is a strong need to search for new drugs that will be effective in the fight against cancer. The chemotherapeutics currently available to oncologists… read more here.
Keywords: lung cancer; personalized therapies; side effects; treatment ... See more keywords