An evolutionary perspective of regulatory landscape dynamics in development and disease.
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DOI: 10.1016/j.ceb.2018.06.009
Abstract: The organization of animal genomes into topologically associating domains (TADs) provides a structural scaffold in which cis-regulatory elements (CREs) operate on their target genes. Determining the position of CREs and genes relative to TADs has… read more here.
Keywords: landscape dynamics; evolutionary perspective; gene expression; disease ... See more keywords