NG2 plays a role in neuroinflammation but is not expressed by immune cells
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica"
DOI: 10.1007/s00401-017-1735-5
Abstract: latter group used a different immunization protocol that included a single administration of 200 μg of MOG and two injections of 400 ng of pertussis toxin (48 h apart). In the present report, we confirm… read more here.
Keywords: pertussis toxin; immunization; ng2 deficient; mice ... See more keywords
Ric-8A-mediated stabilization of the trimeric G protein subunit Gαi is inhibited by pertussis toxin-catalyzed ADP-ribosylation.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.036
Abstract: The heterotrimeric G protein subunit Gαi can be activated by G protein-coupled receptors and the cytosolic protein Ric-8A, the latter of which is also known to prevent ubiquitin-dependent degradation of Gαi. Here we show that… read more here.
Keywords: protein; adp ribosylation; adp ribosylated; protein subunit ... See more keywords
Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110000
Abstract: Prokineticin 1 (pk1) and prokineticin 2 (pk2) interact with two structurally related G-protein coupled receptors, prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2). Cellular signalling studies show that the activated receptors can evoke Ca2+-mobilization,… read more here.
Keywords: protein subtypes; prokineticin receptors; receptor; prokineticin ... See more keywords
Reporter cell lines for detection of pertussis toxin in acellular pertussis vaccines as a functional animal-free alternative to the in vivo histamine sensitization test.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.01.011
Abstract: Detoxified pertussis toxin (pertussis toxoid) is a major antigen in acellular pertussis vaccines. Testing these vaccines on the presence of residual pertussis toxin (PTx) and reversion to toxicity is performed by the regulatory required in… read more here.
Keywords: cell lines; reporter cell; pertussis; cell ... See more keywords
Determination of serum neutralizing antibodies reveals important difference in quality of antibodies against pertussis toxin in children after infection.
Sign Up to like & getrecommendations! Published in 2021 at "Vaccine"
DOI: 10.1016/j.vaccine.2021.02.045
Abstract: OBJECTIVES To determine neutralizing antibodies to pertussis toxin (PTNAs) in children with suspected pertussis and to compare results of PTNAs and anti-PT IgG antibodies. METHODS 172 hospitalized children with suspected pertussis were included. Pertussis was… read more here.
Keywords: antibodies pertussis; infection; igg antibodies; neutralizing antibodies ... See more keywords
Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01153-3
Abstract: The mutant gdPT R9K/E129G is a genetically detoxified variant of the pertussis toxin (PTx) and represents an attractive candidate for the development of improved pertussis vaccines. The impact of the mutations on the overall protein… read more here.
Keywords: immunogenicity; gdpt; structure; pertussis ... See more keywords
Humanised monoclonal antibodies neutralise pertussis toxin by receptor blockade and reduced retrograde trafficking
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Microbiology"
DOI: 10.1111/cmi.12948
Abstract: Pertussis toxin (PTx) is a major protective antigen produced by Bordetella pertussis that is included in all current acellular vaccines. Of several well‐characterized monoclonal antibodies binding this toxin, the humanised hu1B7 and hu11E6 antibodies are… read more here.
Keywords: receptor; pertussis toxin; ptx; retrograde trafficking ... See more keywords
Aluminum hydroxide adjuvant diverts the uptake and trafficking of genetically detoxified pertussis toxin to lysosomes in macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Microbiology"
DOI: 10.1111/mmi.14900
Abstract: Aluminum salts have been successfully utilized as adjuvants to enhance the immunogenicity of vaccine antigens since the 1930s. However, the cellular mechanisms behind the immune adjuvanticity effect of these materials in antigen‐presenting cells are poorly… read more here.
Keywords: aluminum; pertussis toxin; uptake trafficking; genetically detoxified ... See more keywords
Characterization of Individual Human Antibodies That Bind Pertussis Toxin Stimulated by Acellular Immunization
Sign Up to like & getrecommendations! Published in 2018 at "Infection and Immunity"
DOI: 10.1128/iai.00004-18
Abstract: ABSTRACT Despite high vaccination rates, the incidence of whooping cough has steadily been increasing in developing countries for several decades. The current acellular pertussis (aP) vaccines all include the major protective antigen pertussis toxin (PTx)… read more here.
Keywords: immunization; antibodies bind; ptx; individual human ... See more keywords
Contribution of a Novel Pertussis Toxin-Like Factor in Mediating Persistent Otitis Media
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.795230
Abstract: Chronic otitis media (COM) is the long-term infection and inflammation of the middle ears typically caused by upper respiratory tract pathogens that are able to ascend the Eustachian tube. Our understanding of contributing factors is… read more here.
Keywords: pertussis toxin; like factor; toxin; otitis media ... See more keywords
Association of Pertussis Toxin with Severe Pertussis Disease
Sign Up to like & getrecommendations! Published in 2019 at "Toxins"
DOI: 10.3390/toxins11070373
Abstract: Pertussis, caused by respiratory tract infection with the bacterial pathogen Bordetella pertussis, has long been considered to be a toxin-mediated disease. Bacteria adhere and multiply extracellularly in the airways and release several toxins, which have… read more here.
Keywords: pertussis disease; disease; pertussis; severe pertussis ... See more keywords