Three cysteine residues of SLC52A1, a receptor for the porcine endogenous retrovirus-A (PERV-A), play a critical role in cell surface expression and infectivity.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2017.04.019
Abstract: Porcine endogenous retrovirus-A (PERV-A), a gammaretrovirus, infects human cells in vitro, thus raising the potential risk of cross-species transmission in xenotransplantation. Two members of the solute carrier family 52 (SLC52A1 and SLC52A2) are PERV-A receptors.… read more here.
Keywords: receptor; cysteine residues; surface expression; perv ... See more keywords
Unexpected low expression of porcine endogenous retroviruses (PERVs) in porcine expanded potential stem cells (EPSCs).
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DOI: 10.1016/j.virusres.2021.198295
Abstract: Expanded potential stem cells (EPSCs) have been recently derived from porcine preimplantation embryos (Gao et al., 2019). These cells were shown to express key pluripotency genes, to be genetically stable and differentiate to derivatives of… read more here.
Keywords: perv; porcine; endogenous retroviruses; expression ... See more keywords
Genetic engineering: Pigs without PERVs
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DOI: 10.1038/nrg.2017.73
Abstract: Pig-to-human organ transplantation holds promise for resolving the existing shortage of transplantable organs, but the potential transmission risk of porcine endogenous retroviruses (PERVs) to humans has remained a concern. Now, Niu et al. report the… read more here.
Keywords: perv inactivated; perv inactivation; perv; genetic engineering ... See more keywords
Isolation of an Ecotropic Porcine Endogenous Retrovirus PERV-C from a Yucatan SLAD/D Inbred Miniature Swine
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DOI: 10.1128/jvi.00062-23
Abstract: Yucatan SLAD/D haplotype miniature swine are candidates as organ donors for xenotransplantation. A full-length replication-competent PERV-C provirus was characterized. The provirus was chromosomally mapped in the pig genome. In vitro, the virus showed increased infectivity… read more here.
Keywords: full length; miniature swine; provirus; perv ... See more keywords
High Prevalence of Recombinant Porcine Endogenous Retroviruses (PERV-A/Cs) in Minipigs: A Review on Origin and Presence
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DOI: 10.3390/v13091869
Abstract: Minipigs play an important role in biomedical research and they have also been used as donor animals for preclinical xenotransplantations. Since zoonotic microorganisms including viruses can be transmitted when pig cells, tissues or organs are… read more here.
Keywords: high prevalence; perv; porcine endogenous; endogenous retroviruses ... See more keywords
Selective human cells in vitro transduction with porcine endogenous retrovirus (PERV).
Sign Up to like & getrecommendations! Published in 2022 at "Acta virologica"
DOI: 10.4149/av_2022_201
Abstract: Porcine xenograft transplantation raises concerns in humans about the risk of infection with porcine endogenous retroviruses (PERV) as they are an integral part of the pig genome and are therefore very difficult to exclude. In… read more here.
Keywords: human cells; sequence; perv; porcine endogenous ... See more keywords