Novel Bivalent mRNA‐LNP Vaccine for Highly Effective Protection against Pneumonic Plague
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202501286
Abstract: Yersinia pestis, the causative agent of plague, remains a significant global health hazard and a potential top‐tier biothreat despite modern medical advances. Here, two mRNA constructs encoding different versions of the low‐calcium response virulence (LcrV)… read more here.
Keywords: protection; pestis; mrna; pneumonic plague ... See more keywords
Yersinia pestis Actively Inhibits the Production of Extracellular Vesicles by Human Neutrophils
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.70074
Abstract: ABSTRACT Yersinia pestis is the etiologic agent of the plague. A hallmark of plague is subversion of the host immune response by disrupting host signalling pathways required for inflammation. This non‐inflammatory environment permits bacterial colonization… read more here.
Keywords: yersinia pestis; pestis; human neutrophils; pestis actively ... See more keywords
Investigation of Yersinia pestis and Yersinia pseudotuberculosis strains from Georgia and neighboring countries in the Caucasus by high-density SNP microarray
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Microbiology"
DOI: 10.1007/s00203-018-1545-8
Abstract: Yersinia pestis, the causative agent of plague, is a recently evolved clone of the enteropathogenic bacterium Yersinia pseudotuberculosis. Y. pestis has been extensively studied for decades; however, there are insufficient data about the intra-species diversity… read more here.
Keywords: microarray; pestis; yersinia; yersinia pestis ... See more keywords
Oral vaccination against plague using Yersinia pseudotuberculosis.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2016.03.030
Abstract: Yersinia pestis, the agent of plague, is among the deadliest bacterial pathogens affecting humans, and is a potential biological weapon. Because antibiotic resistant strains of Yersinia pestis have been observed or could be engineered for… read more here.
Keywords: plague; pestis; vaccine; vaccination ... See more keywords
Plasmid-mediated doxycycline resistance in a Yersinia pestis strain isolated from a rat.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2017.09.015
Abstract: The emergence of antibiotic-resistant Yersinia pestis strains represents a public health concern. Two antibiotic-resistant Y. pestis strains isolated from Madagascar have been previously identified and characterised. Both strains carried conjugative plasmids that conferred resistance to… read more here.
Keywords: pestis strain; pestis strains; pestis; resistance ... See more keywords
Single-dose intranasal subunit vaccine rapidly clears secondary sepsis in a high-dose pneumonic plague infection.
Sign Up to like & getrecommendations! Published in 2021 at "Vaccine"
DOI: 10.1016/j.vaccine.2021.01.040
Abstract: Yersinia pestis, the causative agent of plague, has killed millions throughout human history. Though public health initiatives have reduced the number of plague cases, it remains endemic in many areas of the world. It also… read more here.
Keywords: plague; pestis; tmv; histopathology ... See more keywords
Inhibition of the Yersinia pestis Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis by α-Phenyl-Substituted Reverse Fosmidomycin Analogues
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.9b04171
Abstract: Fosmidomycin inhibits IspC (1-deoxy-d-xylulose 5-phosphate reductoisomerase), the first committed enzyme in the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis. The MEP pathway of isoprenoid biosynthesis is essential to the causative agent of the plague, Yersinia… read more here.
Keywords: isoprenoid biosynthesis; pestis; pathway isoprenoid; phosphate ... See more keywords
A protein O-GlcNAc glycosyltransferase regulates the antioxidative response in Yersinia pestis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50959-w
Abstract: Post-translational addition of O-linked N-acetylglucosamine (O-GlcNAc) to proteins is commonly associated with a variety of stress responses and cellular processes in eukaryotes, but its potential roles in bacteria are unclear. Here, we show that protein… read more here.
Keywords: yersinia pestis; pestis; stress responses; regulates antioxidative ... See more keywords
Hotspots of genetic change in Yersinia pestis
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DOI: 10.1038/s41467-024-55581-4
Abstract: The relative contributions of mutation rate variation, selection, and recombination in shaping genomic variation in bacterial populations remain poorly understood. Here we analyze 3318 Yersinia pestis genomes, spanning nearly a century and including 2336 newly… read more here.
Keywords: yersinia pestis; pestis; variation; selection ... See more keywords
Genomic diversity and transmission patterns of Yersinia pestis in Inner Mongolia Autonomous Region, China
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DOI: 10.1038/s42003-024-07190-6
Abstract: According to WHO, plague, caused by Yersinia pestis, has resurged since 2000. Inner Mongolia, harboring a quarter of China’s plague foci, has accounted for 80% of national plague cases in the past five years. Despite… read more here.
Keywords: transmission; yersinia pestis; pestis; inner mongolia ... See more keywords
Integrative approach using Yersinia pestis genomes to revisit the historical landscape of plague during the Medieval Period
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1812865115
Abstract: Significance While our knowledge of modern plague reservoirs and their hosts is extensive, we have little to no knowledge about the origin of the Medieval plague pandemics or the routes of transmission involved in their… read more here.
Keywords: medieval period; plague; pestis; yersinia pestis ... See more keywords