PET probes for imaging pancreatic islet cells
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Translational Imaging"
DOI: 10.1007/s40336-017-0251-x
Abstract: PurposePET can detect very low concentrations of the probes at subpicomolar range in the target tissue with high sensitivity. The development of PET probes for imaging pancreatic islet cells depends on several key elements: the… read more here.
Keywords: imaging pancreatic; pancreatic islet; probes imaging; pet probes ... See more keywords
BCPP compounds, PET probes for early therapeutic evaluations, specifically bind to mitochondrial complex I.
Sign Up to like & getrecommendations! Published in 2019 at "Mitochondrion"
DOI: 10.1016/j.mito.2018.03.001
Abstract: BCPP compounds have been developed as PET imaging probes for neurodegenerative diseases in the living brain. 18F-BCPP-EF identifies damaged neuronal areas based on the lack of MC-I; however, its underlying mechanisms of action and specificity… read more here.
Keywords: probes early; early therapeutic; bcpp compounds; pet probes ... See more keywords
Preclinical Evaluation of Novel PET Probes for Dementia.
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in nuclear medicine"
DOI: 10.1053/j.semnuclmed.2023.03.004
Abstract: The development of novel PET imaging agents that selectively bind specific dementia-related targets can contribute significantly to accurate, differential and early diagnosis of dementia causing diseases and support the development of therapeutic agents. Consequently, in… read more here.
Keywords: evaluation; preclinical evaluation; pet probes; pet ... See more keywords
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2140315
Abstract: Abstract Aggregates of the protein α-synuclein are associated with pathophysiology of Parkinson’s disease and are present in Lewy Bodies found in the brains of Parkinson’s patients. We previously demonstrated that bifunctional compounds composed of caffeine… read more here.
Keywords: pet probes; phase; vitro phase; phase kinetics ... See more keywords