In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-020-01544-2
Abstract: Purpose In vivo imaging of programmed death ligand 1 (PD-L1) during immunotherapy could potentially monitor changing PD-L1 expression and PD-L1 expression heterogeneity within and across tumors. Some protein constructs can be used for same-day positron… read more here.
Keywords: affibody; affinity; lox; pet tracer ... See more keywords
[18F]ZCDD083: A PFKFB3-Targeted PET Tracer for Atherosclerotic Plaque Imaging.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00677
Abstract: PFKFB3, a glycolysis-related enzyme upregulated in inflammatory conditions and angiogenesis, is an emerging target for diagnosis and therapy of atherosclerosis. The fluorinated phenoxindazole [18F]ZCDD083 was synthesized, radiolabeled in 17 ± 5% radiochemical yield and >99%… read more here.
Keywords: zcdd083; 18f zcdd083; zcdd083 pfkfb3; pet tracer ... See more keywords
The PET tracer [11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abg3684
Abstract: Description [11C]MK-6884 is an M4R-specific PET tracer for quantifying target engagement in brain and providing insights into AD neuropathology. Quantifying M4R engagement Activation of the M4 muscarinic receptor (M4R) might be therapeutic in patients with… read more here.
Keywords: target engagement; 11c 6884; m4r; pet tracer ... See more keywords
Development of a CD19 PET tracer for detecting B cells in a mouse model of multiple sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01880-8
Abstract: Background B cells play a central role in multiple sclerosis (MS) through production of injurious antibodies, secretion of pro-inflammatory cytokines, and antigen presentation. The therapeutic success of monoclonal antibodies (mAbs) targeting B cells in some… read more here.
Keywords: cd19 pet; cd19; pet; multiple sclerosis ... See more keywords
An 89Zr-HDL PET Tracer Monitors Response to a CSF1R Inhibitor
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Nuclear Medicine"
DOI: 10.2967/jnumed.119.230466
Abstract: The immune function within the tumor microenvironment has become a prominent therapeutic target, with tumor-associated macrophages (TAMs) playing a critical role in immune suppression. We propose an 89Zr-labeled high-density lipoprotein (89Zr-HDL) nanotracer as a means… read more here.
Keywords: response; csf1r inhibitor; hdl; 89zr hdl ... See more keywords