Abstract B033: Petosemtamab (MCLA-158) monotherapy or with chemotherapy in metastatic colorectal cancer: Preliminary antitumor activity and safety data from a phase 2 trial
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-25-b033
Abstract: EGFR is a known oncogenic driver in colorectal cancer (CRC). The leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) is expressed in CRC stem-like cells and drives tumor initiation, growth and metastasis. Petosemtamab, a human, common… read more here.
Keywords: colorectal cancer; cancer; petosemtamab; phase trial ... See more keywords
Abstract CT012: Clinical activity of MCLA-158 (petosemtamab), an IgG1 bispecific antibody targeting EGFR and LGR5, in advanced head and neck squamous cell cancer (HNSCC)
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DOI: 10.1158/1538-7445.am2023-ct012
Abstract: EGFR is a known driver of cancer growth, and leucine-rich, repeat-containing, G-protein coupled receptor 5 (LGR5) is a transmembrane receptor expressed on cancer stem cells. Petosemtamab is a human, common light chain, IgG1 bispecific antibody… read more here.
Keywords: lgr5; igg1 bispecific; petosemtamab; activity ... See more keywords
Abstract CT156: MCLA-158 (petosemtamab), an IgG1 bispecific antibody targeting EGFR and LGR5, in advanced gastric/esophageal adenocarcinoma (GEA)
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct156
Abstract: The epidermal growth factor receptor (EGFR) is a known driver of cancer growth and the leucine-rich, repeat-containing, G-protein coupled receptor 5 (LGR5) is a transmembrane receptor expressed on cancer stem cells. Petosemtamab is a human,… read more here.
Keywords: lgr5; igg1 bispecific; petosemtamab; bispecific antibody ... See more keywords