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   Articles with "pex1" as a keyword



PEX1 is a mediator of α1‐adrenergic signaling attenuating doxorubicin‐induced cardiotoxicity

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recommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.23196

Abstract: Doxorubicin (DOX) is a potent chemotherapeutic agent used for cancer treatment, however, DOX‐induced cardiotoxicity is a serious clinical problem because it causes acute and chronic heart dysfunction. Many studies have indicated that the α1‐adrenergic receptor… read more here.

Keywords: induced cardiotoxicity; pex1; adrenergic signaling; dox induced ... See more keywords
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Compound heterozygous p. Arg949Trp and p. Gly970Ala mutations deteriorated the function of PEX1p: A study on PEX1 in a patient with Zellweger syndrome

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recommendations! Published in 2021 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.29945

Abstract: The peroxisome is responsible for a variety of vital pathways in primary metabolism, including the very long‐chain fatty‐acid oxidation and plasmalogen lipid biosynthesis. Autosomal recessive disorder of the Zellweger spectrum (ZSD) is a major subset… read more here.

Keywords: study; pex1; arg949trp gly970ala; zellweger ... See more keywords

A longitudinal study of retinopathy in the PEX1-Gly844Asp mouse model for mild Zellweger Spectrum Disorder.

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recommendations! Published in 2019 at "Experimental eye research"

DOI: 10.1016/j.exer.2019.107713

Abstract: Zellweger Spectrum Disorder (ZSD) is an autosomal recessive disease caused by mutations in any one of 13 PEX genes whose protein products are required for peroxisome assembly. Retinopathy leading to blindness is one of the… read more here.

Keywords: zellweger spectrum; pex1 gly844asp; spectrum disorder; pex1 ... See more keywords

Regulation of pexophagy by a novel TBK1-MARCHF7-PXMP4-NBR1 Axis in PEX1-depleted HeLa cells.

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recommendations! Published in 2025 at "Autophagy"

DOI: 10.1080/15548627.2025.2593585

Abstract: Peroxisomes are essential for lipid metabolism and redox balance, with pexophagy playing a critical role in maintaining cellular homeostasis. However, the regulatory mechanisms of pexophagy remain unclear. Through functional screening, we identified MARCHF7 as a… read more here.

Keywords: marchf7 pxmp4; tbk1 marchf7; marchf7; pxmp4 ... See more keywords

The PEX1 ATPase Stabilizes PEX6 and Plays Essential Roles in Peroxisome Biology1[OPEN]

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recommendations! Published in 2017 at "Plant Physiology"

DOI: 10.1104/pp.17.00548

Abstract: Novel missense alleles of the Arabidopsis PEX1 ATPase reveal essential peroxisomal roles that impact embryogenesis and plant growth. A variety of metabolic pathways are sequestered in peroxisomes, conserved organelles that are essential for human and… read more here.

Keywords: atpase stabilizes; pex1; pex1 pex1; growth ... See more keywords

The lignin-degrading abilities of Gelatoporia subvermispora gat1 and pex1 mutants generated via CRISPR/Cas9.

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recommendations! Published in 2023 at "Environmental microbiology"

DOI: 10.1111/1462-2920.16372

Abstract: White-rot fungi efficiently degrade wood lignin; however, the mechanisms involved remain largely unknown. Recently, a forward genetics approach to identify several genes in Pleurotus ostreatus (Agaricales) in which mutations cause defects in wood lignin degradation… read more here.

Keywords: crispr cas9; lignin; gat1; pex1 ... See more keywords

Comparison of human PEX knockout cell lines suggests a dual role of PEX1 in peroxisome biogenesis

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recommendations! Published in 2022 at "Biological Chemistry"

DOI: 10.1515/hsz-2022-0223

Abstract: Abstract For the biogenesis and maintenance of peroxisomes several proteins, called peroxins, are essential. Malfunctions of these proteins lead to severe diseases summarized as peroxisome biogenesis disorders. The different genetic background of patient-derived cell lines… read more here.

Keywords: cell; pex1; biogenesis; cell lines ... See more keywords

Extensin-like Protein OsPEX1 Modulates Grain Filling in Rice

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recommendations! Published in 2025 at "Plants"

DOI: 10.3390/plants14172723

Abstract: Grain filling is a vital factor influencing both rice grain yield and quality, yet its underlying mechanisms remain poorly understood. In this study, we perform a functional analysis of the grain-filling defective mutant pex1 in… read more here.

Keywords: extensin like; rice; grain filling; like protein ... See more keywords