GWAS links variants in neuronal development and actin remodeling related loci with pseudoexfoliation syndrome without glaucoma
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2017.12.006
Abstract: ABSTRACT Pseudoexfoliation syndrome (PEXS) is an age‐related elastosis, strongly associated with the development of secondary glaucoma. It is clearly suggested that PEXS has a genetic component, but this has not been extensively studied. Here, a… read more here.
Keywords: snps; pexs; without glaucoma; neuronal development ... See more keywords
Epigenetic silencing of heat shock protein 70 through DNA hypermethylation in pseudoexfoliation syndrome and glaucoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Human Genetics"
DOI: 10.1038/s10038-020-0736-8
Abstract: This study is intended to investigate the epigenetic regulation of the most conserved molecular chaperone, HSP70 and its potential role in the pathophysiology of pseudoexfoliation syndrome (PEXS) and glaucoma (PEXG), a protein aggregopathy, contributing significantly… read more here.
Keywords: hsp70; hypermethylation; pexs; pseudoexfoliation syndrome ... See more keywords