Imaging Mass Cytometry‐Based Immune Profiling of Human Peyer's Patches in Patients with Crohn's Disease
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Immunology"
DOI: 10.1002/eji.70071
Abstract: Lymphoid follicles in the human gut are critical immune hubs, yet their role in Crohn's disease pathogenesis remains poorly understood. Here, we apply multiplexed imaging mass cytometry to spatially profile Peyer's patches and lymphoid follicles… read more here.
Keywords: disease; crohn disease; cell; imaging mass ... See more keywords
IL-22 in Peyer's patches
Sign Up to like & getrecommendations! Published in 2017 at "Nature Immunology"
DOI: 10.1038/ni.3786
Abstract: Pneumonia is caused by pathobionts present in the respiratory tract, such as Streptococcus pneumoniae. In Mucosal Immunology, Mizgerd and colleagues show that resistance to pneumonia is provided by highly localized resident memory T cells (TRM… read more here.
Keywords: protection; peyer patches; immunology; trm cells ... See more keywords
CD122-targetted IL-2 signals cause acute and selective apoptosis of B cells in Peyer’s Patches
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69632-5
Abstract: Interleukin-2 (IL-2) has both pro- and anti-inflammatory properties that have been harnessed clinically and that are used experimentally to modulate leukocyte subsets in vivo. In mice, the bioavailability and half-life of IL-2 in vivo can… read more here.
Keywords: signals cause; targetted signals; acute selective; cd122 targetted ... See more keywords
Regional heterogeneity in rat Peyer’s patches through whole transcriptome analysis
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370220973014
Abstract: Peyer’s patches are gut-associated lymphoid tissue located throughout the intestinal wall. Peyer’s patches consist of highly organized ovoid-shaped follicles, classified as non-encapsulated lymphatic tissues, populated with B cells, T cells, macrophages, and dendritic cells and… read more here.
Keywords: transcriptome analysis; whole transcriptome; regional heterogeneity; peyer ... See more keywords
Distinct B cell subsets in Peyer’s patches convey probiotic effects by Limosilactobacillus reuteri
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DOI: 10.1186/s40168-021-01128-4
Abstract: Background Intestinal Peyer’s patches (PPs) form unique niches for bacteria-immune cell interactions that direct host immunity and shape the microbiome. Here we investigate how peroral administration of probiotic bacterium Limosilactobacillus reuteri R2LC affects B lymphocytes… read more here.
Keywords: peyer patches; cell subsets; distinct cell; subsets peyer ... See more keywords
The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02345
Abstract: Microfold (M) cells are located in the epithelium covering mucosa-associated lymphoid tissues, such as the Peyer's patches (PPs) of the small intestine. M cells actively transport luminal antigens to the underlying lymphoid follicles to initiate… read more here.
Keywords: microfold cells; autoimmune; autoimmune diseases; immune system ... See more keywords
Organogenesis of Ileal Peyer's Patches Is Initiated Prenatally and Accelerated Postnatally With Comprehensive Proliferation of B Cells in Pigs
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.604674
Abstract: Morphogenesis and differentiation of organs is required for subsequent functional maturation. The morphological features of Peyer's patches vary among species. In pigs, they develop extensively in the ileum as ileal Peyer's patches (IPPs). However, the… read more here.
Keywords: initiated prenatally; peyer patches; organogenesis; ileal peyer ... See more keywords
Aging-Related Impairments to M Cells in Peyer’s Patches Coincide With Disturbances to Paneth Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.761949
Abstract: The decline in mucosal immunity during aging increases susceptibility, morbidity and mortality to infections acquired via the gastrointestinal and respiratory tracts in the elderly. We previously showed that this immunosenescence includes a reduction in the… read more here.
Keywords: aged mice; paneth cells; peyer patches; aging related ... See more keywords
Intestinal microbiota regulates naïve lymphocyte migration in Peyer’s patches
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1717788
Abstract: Peyer’s patches (PPs) are lymphoid organs in the small intestine that serve as inductive sites for both humoral and cellular immune responses against the microbiota, food antigens and pathogens. PPs in germ-free mice are small… read more here.
Keywords: lymphocyte migration; migration; intestinal microbiota; peyer patches ... See more keywords
Barrier Perturbation in Porcine Peyer’s Patches by Tumor Necrosis Factor is Associated With a Dysregulation of Claudins
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.889552
Abstract: The proinflammatory cytokine tumor necrosis factor (TNF) has been described as one of the main mediators of intestinal inflammatory diseases, affecting the composition of tight junction (TJ) proteins and leading to a disruption of the… read more here.
Keywords: necrosis factor; peyer; peyer patches; tumor necrosis ... See more keywords
Commensal microbiota modulates phenotypic characteristics and gene expression in piglet Peyer’s patches
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1084332
Abstract: The gastrointestinal tract contains a complex microbial community. Peyer’s patches (PPs) play an important role in inducing mucosal immune responses in the gastrointestinal tract. However, little is known about the effect of commensal microbiota on… read more here.
Keywords: commensal microbiota; characteristics gene; peyer patches; expression ... See more keywords