Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance
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DOI: 10.1073/pnas.1806109115
Abstract: Significance Protozoal proteasome is a validated target for antimalarial drug development, but species selectivity of reported inhibitors is suboptimal. Here we identify inhibitors with improved selectivity for malaria proteasome β5 subunit over each active subunit… read more here.
Keywords: fitness cost; inhibitor; proteasome; resistance ... See more keywords