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   Articles with "pf4" as a keyword



Persistence of Ad26.COV2.S-associated VITT and specific detection of VITT antibodies.

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recommendations! Published in 2022 at "American journal of hematology"

DOI: 10.1002/ajh.26488

Abstract: Rare cases of COVID-19 vaccinated individuals develop anti-platelet factor 4 (PF4) antibodies that cause thrombocytopenia and thrombotic complications, a syndrome referred to as vaccine-induced immune thrombotic thrombocytopenia (VITT). Currently, information on the characteristics and persistence… read more here.

Keywords: cov2; cov2 associated; associated vitt; ad26 cov2 ... See more keywords
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Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly.

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recommendations! Published in 2020 at "Biophysical journal"

DOI: 10.1016/j.bpj.2020.04.012

Abstract: Association of platelet factor 4 (PF4) with heparin is a first step in formation of aggregates implicated in the development of heparin-induced thrombocytopenia (HIT), a potentially fatal immune disorder affecting 1-5% of patients receiving heparin.… read more here.

Keywords: heparin; short heparin; heparin oligomers; platelet factor ... See more keywords

Molecular architecture and platelet-activating properties of small immune complexes assembled on heparin and platelet factor 4

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recommendations! Published in 2024 at "Communications Biology"

DOI: 10.1038/s42003-024-05982-4

Abstract: Heparin-induced thrombocytopenia (HIT) is an adverse reaction to heparin leading to a reduction in circulating platelets with an increased risk of thrombosis. It is precipitated by polymerized immune complexes consisting of pathogenic antibodies that recognize… read more here.

Keywords: pf4; platelet; immune complexes; assembled heparin ... See more keywords

Platelet-activating anti-PF4 disorders: An overview.

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recommendations! Published in 2022 at "Seminars in hematology"

DOI: 10.1053/j.seminhematol.2022.02.005

Abstract: Platelet factor 4 (PF4) is a highly cationic tetrameric protein that can be targeted by platelet-activating anti-PF4 antibodies of immunoglobulin G (IgG) class. Certain features of PF4, including its multivalent nature (duplicate antigen sites per… read more here.

Keywords: platelet activating; pf4 disorders; pf4; activating anti ... See more keywords
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Characterization of New Monoclonal PF4-Specific Antibodies as Useful Tools for Studies on Typical and Autoimmune Heparin-Induced Thrombocytopenia.

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recommendations! Published in 2020 at "Thrombosis and haemostasis"

DOI: 10.1055/s-0040-1717078

Abstract: BACKGROUND  Heparin-induced thrombocytopenia (HIT) is typically caused by platelet-activating immunoglobulin G (IgG) antibodies (Abs) against platelet factor 4 (PF4) complexed with heparin (H). Much less frequent "autoimmune" HIT is distinguished from typical HIT by platelet… read more here.

Keywords: heparin; induced thrombocytopenia; autoimmune hit; heparin induced ... See more keywords

Development of a high-yield expression and purification system for platelet factor 4

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recommendations! Published in 2018 at "Platelets"

DOI: 10.1080/09537104.2017.1378808

Abstract: Abstract Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characterized by IgG antibodies bound to complexes of platelet factor 4 (PF4) and heparin. The majority of diagnostic tests for HIT rely on an exogenous source… read more here.

Keywords: heparin; pf4 heparin; system; method ... See more keywords

Tripartite interactions between filamentous Pf4 bacteriophage, Pseudomonas aeruginosa, and bacterivorous nematodes

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recommendations! Published in 2022 at "PLOS Pathogens"

DOI: 10.1101/2022.10.11.511824

Abstract: The opportunistic pathogen Pseudomonas aeruginosa PAO1 is infected by the filamentous bacteriophage Pf4. Pf4 virions promote biofilm formation, protect bacteria from antibiotics, and modulate animal immune responses in ways that promote infection. Furthermore, strains cured… read more here.

Keywords: pseudomonas aeruginosa; infection; pf4; virulence ... See more keywords
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Protect thy host: Pf4 phages shield P. aeruginosa from antibiotics.

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recommendations! Published in 2020 at "Environmental microbiology"

DOI: 10.1111/1462-2920.15046

Abstract: Bacterial viruses or bacteriophages exert profound effects on host cell lifestyle and evolution. The prophage Pf4 in P. aeruginosa is highly induced in biofilms and is shown to confer antibiotic resistance to the bacterium. A… read more here.

Keywords: protect thy; pf4 phages; host pf4; host ... See more keywords
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Platelet factor 4 triggers thrombo-inflammation by bridging innate and adaptive immunity.

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recommendations! Published in 2023 at "International journal of laboratory hematology"

DOI: 10.1111/ijlh.14075

Abstract: Platelet factor 4 (PF4, synonym: CXCL4) is an evolutionary old chemokine with proposed roles in hemostasis and antimicrobial defense. In addition, PF4 has attracted considerable attention as a crucial mediator of one of the most… read more here.

Keywords: hit vitt; vitt antibodies; pf4; platelet ... See more keywords
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Reactivity of platelet‐activating and nonplatelet‐activating anti‐PF4/heparin antibodies in enzyme immunosorbent assays under different conditions

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recommendations! Published in 2019 at "Journal of Thrombosis and Haemostasis"

DOI: 10.1111/jth.14455

Abstract: Essentials At low pH and low salt concentrations: Maximal conformational change of PF4 upon complexation with heparin occurs. Changing physicochemical conditions may become an approach to better discriminate the signal of platelet‐activating‐ and nonactivating PF4/H… read more here.

Keywords: heparin; platelet activating; reactivity platelet; activating nonplatelet ... See more keywords

The c-di-GMP Phosphodiesterase PipA (PA0285) Regulates Autoaggregation and Pf4 Bacteriophage Production in Pseudomonas aeruginosa PAO1

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recommendations! Published in 2022 at "Applied and Environmental Microbiology"

DOI: 10.1128/aem.00039-22

Abstract: The c-di-GMP signaling pathways in P. aeruginosa are highly organized and well coordinated, with different diguanylate cyclases and phosphodiesterases playing distinct roles in a complex network. Understanding the function of each enzyme and the underlying… read more here.

Keywords: pipa; bacteriophage production; production; pf4 ... See more keywords