Persistence of Ad26.COV2.S-associated VITT and specific detection of VITT antibodies.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of hematology"
DOI: 10.1002/ajh.26488
Abstract: Rare cases of COVID-19 vaccinated individuals develop anti-platelet factor 4 (PF4) antibodies that cause thrombocytopenia and thrombotic complications, a syndrome referred to as vaccine-induced immune thrombotic thrombocytopenia (VITT). Currently, information on the characteristics and persistence… read more here.
Keywords: cov2; cov2 associated; associated vitt; ad26 cov2 ... See more keywords
Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.04.012
Abstract: Association of platelet factor 4 (PF4) with heparin is a first step in formation of aggregates implicated in the development of heparin-induced thrombocytopenia (HIT), a potentially fatal immune disorder affecting 1-5% of patients receiving heparin.… read more here.
Keywords: heparin; short heparin; heparin oligomers; platelet factor ... See more keywords
Platelet-activating anti-PF4 disorders: An overview.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in hematology"
DOI: 10.1053/j.seminhematol.2022.02.005
Abstract: Platelet factor 4 (PF4) is a highly cationic tetrameric protein that can be targeted by platelet-activating anti-PF4 antibodies of immunoglobulin G (IgG) class. Certain features of PF4, including its multivalent nature (duplicate antigen sites per… read more here.
Keywords: platelet activating; pf4 disorders; pf4; activating anti ... See more keywords
Characterization of New Monoclonal PF4-Specific Antibodies as Useful Tools for Studies on Typical and Autoimmune Heparin-Induced Thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2020 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0040-1717078
Abstract: BACKGROUND Heparin-induced thrombocytopenia (HIT) is typically caused by platelet-activating immunoglobulin G (IgG) antibodies (Abs) against platelet factor 4 (PF4) complexed with heparin (H). Much less frequent "autoimmune" HIT is distinguished from typical HIT by platelet… read more here.
Keywords: heparin; induced thrombocytopenia; autoimmune hit; heparin induced ... See more keywords
Development of a high-yield expression and purification system for platelet factor 4
Sign Up to like & getrecommendations! Published in 2018 at "Platelets"
DOI: 10.1080/09537104.2017.1378808
Abstract: Abstract Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characterized by IgG antibodies bound to complexes of platelet factor 4 (PF4) and heparin. The majority of diagnostic tests for HIT rely on an exogenous source… read more here.
Keywords: heparin; pf4 heparin; system; method ... See more keywords
Tripartite interactions between filamentous Pf4 bacteriophage, Pseudomonas aeruginosa, and bacterivorous nematodes
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1101/2022.10.11.511824
Abstract: The opportunistic pathogen Pseudomonas aeruginosa PAO1 is infected by the filamentous bacteriophage Pf4. Pf4 virions promote biofilm formation, protect bacteria from antibiotics, and modulate animal immune responses in ways that promote infection. Furthermore, strains cured… read more here.
Keywords: pseudomonas aeruginosa; infection; pf4; virulence ... See more keywords
Protect thy host: Pf4 phages shield P. aeruginosa from antibiotics.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental microbiology"
DOI: 10.1111/1462-2920.15046
Abstract: Bacterial viruses or bacteriophages exert profound effects on host cell lifestyle and evolution. The prophage Pf4 in P. aeruginosa is highly induced in biofilms and is shown to confer antibiotic resistance to the bacterium. A… read more here.
Keywords: protect thy; pf4 phages; host pf4; host ... See more keywords
Platelet factor 4 triggers thrombo-inflammation by bridging innate and adaptive immunity.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.14075
Abstract: Platelet factor 4 (PF4, synonym: CXCL4) is an evolutionary old chemokine with proposed roles in hemostasis and antimicrobial defense. In addition, PF4 has attracted considerable attention as a crucial mediator of one of the most… read more here.
Keywords: hit vitt; vitt antibodies; pf4; platelet ... See more keywords
Reactivity of platelet‐activating and nonplatelet‐activating anti‐PF4/heparin antibodies in enzyme immunosorbent assays under different conditions
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14455
Abstract: Essentials At low pH and low salt concentrations: Maximal conformational change of PF4 upon complexation with heparin occurs. Changing physicochemical conditions may become an approach to better discriminate the signal of platelet‐activating‐ and nonactivating PF4/H… read more here.
Keywords: heparin; platelet activating; reactivity platelet; activating nonplatelet ... See more keywords
The c-di-GMP Phosphodiesterase PipA (PA0285) Regulates Autoaggregation and Pf4 Bacteriophage Production in Pseudomonas aeruginosa PAO1
Sign Up to like & getrecommendations! Published in 2022 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.00039-22
Abstract: The c-di-GMP signaling pathways in P. aeruginosa are highly organized and well coordinated, with different diguanylate cyclases and phosphodiesterases playing distinct roles in a complex network. Understanding the function of each enzyme and the underlying… read more here.
Keywords: pipa; bacteriophage production; production; pf4 ... See more keywords
The Relevance of Anti-PF4 Antibody Isotypes and Endogenous Glycosaminoglycans and their Relationship with Inflammatory Biomarkers in Pulmonary Embolism Patients
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Applied Thrombosis/Hemostasis"
DOI: 10.1177/10760296221091770
Abstract: Introduction Previous studies have shown that inflammation may contribute to the interplay of endogenous glycosaminoglycans (GAGs) and anti-PF4 antibodies. In this study, we quantified the levels of anti-PF4 antibody isotypes and endogenous GAGs together with… read more here.
Keywords: anti pf4; inflammatory biomarkers; pf4; antibody isotypes ... See more keywords