Anti-PF4/heparin antibodies are increased in hospitalized patients with bacterial sepsis.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis research"
DOI: 10.1016/j.thromres.2018.09.060
Abstract: Heparin-induced thrombocytopenia (HIT) is caused by antibodies targeting platelet factor 4 (PF4)/heparin complexes. The immune response leading to HIT remains perplexing with many paradoxes. Unlike other drug induced reactions, anti-PF4/heparin antibody generation does not follow… read more here.
Keywords: antibody; sepsis; pf4 heparin; anti pf4 ... See more keywords
Cardiac Surgery Successfully Managed With Cangrelor in a Patient With Persistent Anti-PF4/Heparin Antibodies 8 Years After Heparin-Induced Thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of cardiothoracic and vascular anesthesia"
DOI: 10.1053/j.jvca.2019.06.044
Abstract: A 66-YEAR-OLD female requiring cardiac surgery had persisting anti-platelet factor 4 (PF4)/heparin antibodies (HIT-abs) 8 years after heparin-induced thrombocytopenia (HIT). In 2010, she developed thrombotic thrombocytopenic purpura (TTP) (ADAMTS-13 read more here.
Keywords: heparin antibodies; heparin; pf4 heparin; cardiac surgery ... See more keywords
Development of a high-yield expression and purification system for platelet factor 4
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DOI: 10.1080/09537104.2017.1378808
Abstract: Abstract Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characterized by IgG antibodies bound to complexes of platelet factor 4 (PF4) and heparin. The majority of diagnostic tests for HIT rely on an exogenous source… read more here.
Keywords: heparin; pf4 heparin; system; method ... See more keywords