Differential Retention of Pfam Domains Contributes to Long-term Evolutionary Trends
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DOI: 10.1093/molbev/msad073
Abstract: Abstract Protein domains that emerged more recently in evolution have a higher structural disorder and greater clustering of hydrophobic residues along the primary sequence. It is hard to explain how selection acting via descent with… read more here.
Keywords: long term; retention; loss; pfam domains ... See more keywords
Pfam: The protein families database in 2021
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DOI: 10.1093/nar/gkaa913
Abstract: Abstract The Pfam database is a widely used resource for classifying protein sequences into families and domains. Since Pfam was last described in this journal, over 350 new families have been added in Pfam 33.1… read more here.
Keywords: protein; protein families; families database; pfam ... See more keywords
AlloMAPS 2: allosteric fingerprints of the AlphaFold and Pfam-trRosetta predicted structures for engineering and design
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac828
Abstract: Abstract AlloMAPS 2 is an update of the Allosteric Mutation Analysis and Polymorphism of Signalling database, which contains data on allosteric communication obtained for predicted structures in the AlphaFold database (AFDB) and trRosetta-predicted Pfam domains.… read more here.
Keywords: predicted structures; allomaps allosteric; design; trrosetta predicted ... See more keywords