Occurrence of septuple and elevated Pfdhfr-Pfdhps quintuple mutations in a general population threatens the use of sulfadoxine-pyrimethamine for malaria prevention during pregnancy in eastern-coast of Tanzania
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DOI: 10.1186/s12879-020-05253-7
Abstract: Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthetase (Pfdhps) mutations compromise the effectiveness of sulfadoxine-pyrimethamine (SP) for treatment of uncomplicated malaria, and are likely to impair the efficiency of intermittent preventive treatment during pregnancy (IPTp).… read more here.
Keywords: pfdhfr pfdhps; pfdhps; sulfadoxine pyrimethamine; pfdhfr ... See more keywords
Recent uptake of intermittent preventive treatment during pregnancy with sulfadoxine–pyrimethamine is associated with increased prevalence of Pfdhfr mutations in Bobo-Dioulasso, Burkina Faso
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DOI: 10.1186/s12936-017-1695-1
Abstract: BackgroundThe impact of sulfadoxine–pyrimethamine (SP) used as intermittent preventive treatment during pregnancy (IPTp-SP) on mutant parasite selection has been poorly documented in Burkina Faso. This study sought first to explore the relationship between IPTp-SP and… read more here.
Keywords: pfdhfr; burkina faso; pfdhfr mutations; pregnancy ... See more keywords
Antimalarial drug resistance in the Central and Adamawa regions of Cameroon: Prevalence of mutations in P. falciparum crt, Pfmdr1, Pfdhfr and Pfdhps genes
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DOI: 10.1371/journal.pone.0256343
Abstract: The spread of Plasmodium falciparum resistant parasites remains one of the major challenges for malaria control and elimination in Sub Saharan Africa. Monitoring of molecular markers conferring resistance to different antimalarials is important to track… read more here.
Keywords: drug resistance; prevalence; pfdhps; pfmdr1 pfdhfr ... See more keywords