Molecular Epidemiology of Drug Resistance Genes in Plasmodium falciparum Isolates Imported from Nigeria between 2016 and 2020: Continued Emergence of Fully Resistant Pfdhfr-Pfdhps Alleles
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DOI: 10.1128/spectrum.00528-22
Abstract: Monitoring the current resistance to antimalarial drugs is critical to enable timely action to prevent its spread and limit its impact. The high prevalence of wild-type Pfcrt found in our study is an optimistic signal… read more here.
Keywords: pfdhfr pfdhps; fully resistant; resistance; epidemiology ... See more keywords
Molecular Determinants of Sulfadoxine-Pyrimethamine Resistance in Plasmodium falciparum Isolates from Central Africa between 2016 and 2021: Wide Geographic Spread of Highly Mutated Pfdhfr and Pfdhps Alleles
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DOI: 10.1128/spectrum.02005-22
Abstract: Monitoring drug resistance is important for malaria control because its early detection enables timely action to prevent its spread and mitigate its impact. The wide geographic spread and the increasing trend of highly resistant Pfdhfr… read more here.
Keywords: 2016 2021; central africa; resistance; pfdhfr pfdhps ... See more keywords
Occurrence of septuple and elevated Pfdhfr-Pfdhps quintuple mutations in a general population threatens the use of sulfadoxine-pyrimethamine for malaria prevention during pregnancy in eastern-coast of Tanzania
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DOI: 10.1186/s12879-020-05253-7
Abstract: Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthetase (Pfdhps) mutations compromise the effectiveness of sulfadoxine-pyrimethamine (SP) for treatment of uncomplicated malaria, and are likely to impair the efficiency of intermittent preventive treatment during pregnancy (IPTp).… read more here.
Keywords: pfdhfr pfdhps; pfdhps; sulfadoxine pyrimethamine; pfdhfr ... See more keywords
Ten-year persistence and evolution of Plasmodium falciparum antifolate and anti-sulfonamide resistance markers pfdhfr and pfdhps in three Asian countries
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DOI: 10.1371/journal.pone.0278928
Abstract: Background The amplification of GTP cyclohydrolase 1 (pfgch1) in Plasmodium falciparum has been linked to the upregulation of the pfdhfr and pfdhps genes associated with resistance to the antimalarial drug sulfadoxine-pyrimethamine. During the 1990s and… read more here.
Keywords: plasmodium falciparum; pfdhfr pfdhps; resistance; falciparum ... See more keywords
Prevalence of Mutations in the Pfdhfr, Pfdhps, and Pfmdr1 Genes of Malarial Parasites Isolated from Symptomatic Patients in Dogondoutchi, Niger
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DOI: 10.3390/tropicalmed7080155
Abstract: The effectiveness of artemisinin-based combination therapies (ACTs) depends not only on that of artemisinin but also on that of partner molecules. This study aims to evaluate the prevalence of mutations in the Pfdhfr, Pfdhps, and… read more here.
Keywords: prevalence mutations; pfdhps pfmdr1; mutations pfdhfr; pfmdr1 ... See more keywords