Occurrence of septuple and elevated Pfdhfr-Pfdhps quintuple mutations in a general population threatens the use of sulfadoxine-pyrimethamine for malaria prevention during pregnancy in eastern-coast of Tanzania
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DOI: 10.1186/s12879-020-05253-7
Abstract: Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthetase (Pfdhps) mutations compromise the effectiveness of sulfadoxine-pyrimethamine (SP) for treatment of uncomplicated malaria, and are likely to impair the efficiency of intermittent preventive treatment during pregnancy (IPTp).… read more here.
Keywords: pfdhfr pfdhps; pfdhps; sulfadoxine pyrimethamine; pfdhfr ... See more keywords
Origins and spread of novel genetic variants of sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates in Indonesia
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DOI: 10.1186/s12936-018-2597-6
Abstract: BackgroundWhile malaria incidence in Indonesia has decreased threefold in the last decade, more than 200,000 cases were reported in 2016. Different endemicity of Plasmodium falciparum malaria among several islands in Indonesia has been recognized and… read more here.
Keywords: pfdhps; plasmodium falciparum; resistance; sulfadoxine pyrimethamine ... See more keywords
Effect of three years’ seasonal malaria chemoprevention on molecular markers of resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine and amodiaquine in Ouelessebougou, Mali
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DOI: 10.1186/s12936-022-04059-z
Abstract: Background In 2012, seasonal malaria chemoprevention (SMC) was recommended as policy for malaria control by the World Health Organization (WHO) in areas of highly seasonal malaria transmission across the Sahel sub-region in Africa along with… read more here.
Keywords: falciparum; seasonal malaria; years smc; frequency ... See more keywords
Antimalarial drug resistance in the Central and Adamawa regions of Cameroon: Prevalence of mutations in P. falciparum crt, Pfmdr1, Pfdhfr and Pfdhps genes
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DOI: 10.1371/journal.pone.0256343
Abstract: The spread of Plasmodium falciparum resistant parasites remains one of the major challenges for malaria control and elimination in Sub Saharan Africa. Monitoring of molecular markers conferring resistance to different antimalarials is important to track… read more here.
Keywords: drug resistance; prevalence; pfdhps; pfmdr1 pfdhfr ... See more keywords
The prevalence of molecular markers of resistance to sulfadoxine-pyrimethamine among pregnant women at first antenatal clinic attendance and delivery in the forest-savannah area of Ghana
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DOI: 10.1371/journal.pone.0271489
Abstract: Intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) is used to prevent malaria and associated unfavorable maternal and foetal outcomes in pregnancy in moderate to high malaria transmission areas. Effectiveness of IPTp-SP is, however, threatened… read more here.
Keywords: prevalence; area; pfdhps; among pregnant ... See more keywords