Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study
Sign Up to like & getrecommendations! Published in 2018 at "Neuroimage"
DOI: 10.1016/j.neuroimage.2018.08.075
Abstract: &NA; Higher polygenic risk score for schizophrenia (szPGRS) has been associated with lower cognitive function and might be a predictor of decline in brain structure in apparently healthy populations. Age‐related declines in structural brain connectivity—measured… read more here.
Keywords: age; pfdr; brain; brain connectivity ... See more keywords
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-55704-3
Abstract: Diabetic retinopathy (DR) is the most frequent microvascular complication of diabetes mellitus, however, its underlying biological mechanisms remain poorly understood. We examined single nucleotide polymorphisms linked to 486 blood metabolites through extensive genome-wide association studies… read more here.
Keywords: per one; pfdr; confidence interval; increase ... See more keywords
Exploring the genetic causality of childhood maltreatment on multiple risk-related outcomes using Mendelian randomization: evidence from European-Ancestry GWAS
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Psychotraumatology"
DOI: 10.1080/20008066.2025.2558478
Abstract: ABSTRACT Background: Childhood maltreatment (CM) has been implicated as a risk factor for various maladaptive behaviours in adulthood, but evidence from genetic epidemiology remains limited. This study aimed to assess the potential causal effects of… read more here.
Keywords: evidence; childhood maltreatment; pfdr; risk ... See more keywords
O6.4. ASSOCIATION BETWEEN CLUSTERS OF FORMAL THOUGHT DISORDERS SEVERITY AND NEUROCOGNITIVE AND FUNCTIONAL OUTCOME INDICES IN THE EARLY STAGES OF PSYCHOSIS – RESULTS FROM THE PRONIA COHORT
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa028.033
Abstract: Abstract Background Formal thought disorder (FThD) has been associated with more severe illness courses and functional deficits in psychosis patients. Given these associations, it remains unclear whether the presence of FThD accounts for the heterogeneous… read more here.
Keywords: package; pfdr; fthd; pfdr 0001 ... See more keywords
Associations of Plasma Neurofilament Light Levels With Brain Microstructure and Macrostructure and Cognition in the Community-Based Rhineland Study
Sign Up to like & getrecommendations! Published in 2025 at "Neurology"
DOI: 10.1212/wnl.0000000000210278
Abstract: Background and Objectives Plasma neurofilament light chain (NfL) level is a sensitive yet aspecific marker of neurodegeneration. Its neuroanatomical and functional correlates in the general population are not fully elucidated. We thus assessed how brain's… read more here.
Keywords: plasma nfl; brain; pfdr; community based ... See more keywords
Associations of upper respiratory mucosa microbiota with Rheumatoid arthritis, autoantibodies, and disease activity
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0308010
Abstract: The lung is recognized as a site for initiating the formation of self-antigen and autoimmune responses in rheumatoid arthritis (RA). We aimed to investigate the association of upper respiratory microbiota with RA, autoantibody production, and… read more here.
Keywords: disease activity; upper respiratory; pfdr; activity ... See more keywords
Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2024.1415474
Abstract: Background Pancreatitis is a serious and complex inflammatory disease that imposes a severe effect on quality of life. Links between plasma lipidome and pancreatitis have been reported, some of which have not yet been clearly… read more here.
Keywords: lipidome four; types pancreatitis; pfdr; plasma lipidome ... See more keywords
Causal relationships between gut microbiota and programmed cell death protein 1/programmed cell death-ligand 1: A bidirectional Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1136169
Abstract: Background Multiple clinical studies have indicated that the gut microbiota influences the effects of immune checkpoint blockade (ICB) therapy comprising PD-1/PD-L1 inhibitors, but the causal relationship is unclear. Because of numerous confounders, many microbes related… read more here.
Keywords: ivw pfdr; cell death; microbiota; programmed cell ... See more keywords
The causal role of circulating inflammatory markers in osteoporosis: a bidirectional Mendelian randomized study
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1412298
Abstract: Background Osteoporosis (OP) associated with aging exerts substantial clinical and fiscal strains on societal structures. An increasing number of research studies have suggested a bidirectional relationship between circulating inflammatory markers (CIMs) and OP. However, observational… read more here.
Keywords: circulating inflammatory; pfdr; inflammatory markers; causal ... See more keywords
Modulations of static and dynamic functional connectivity among brain networks by electroacupuncture in post-stroke aphasia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.956931
Abstract: Introduction Post-stroke aphasia (PSA) is a language disorder caused by left hemisphere stroke. Electroacupuncture (EA) is a minimally invasive therapeutic option for PSA treatment. Tongli (HT5) and Xuanzhong (GB39), two important language-associated acupoints, are frequently… read more here.
Keywords: network; stroke aphasia; gyrus; functional connectivity ... See more keywords
Breathomics profiling of metabolic pathways affected by major depression: Possibilities and limitations
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.1061326
Abstract: Background Major depressive disorder (MDD) is one of the most common psychiatric disorders with multifactorial etiologies. Metabolomics has recently emerged as a particularly potential quantitative tool that provides a multi-parametric signature specific to several mechanisms… read more here.
Keywords: breathomics profiling; patients mdd; analysis; possibilities limitations ... See more keywords