Recombinant DBL2β-PfEMP1 of the Indonesian Plasmodium falciparum induces immune responses in Wistar rats
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Taibah University Medical Sciences"
DOI: 10.1016/j.jtumed.2020.12.007
Abstract: Objectives The Duffy binding-like (DBL) domain of the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is reportedly responsible for the pathophysiology of cerebral malaria. People living in endemic malaria areas possess specific antibodies against PfEMP1… read more here.
Keywords: dbl2 pfemp1; immune responses; pfemp1; plasmodium falciparum ... See more keywords
Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1911900116
Abstract: Significance Malaria is one of the deadliest infectious diseases to affect humans, causing over 200 million cases and hundreds of thousands of deaths annually. Its fatal symptoms occur when parasites cause infected human red blood… read more here.
Keywords: type pfemp1; infected erythrocytes; pfemp1; plasmodium falciparum ... See more keywords
Plasmodium falciparum protein 'PfJ23' hosts distinct binding sites for major virulence factor 'PfEMP1' and Maurer's cleft marker 'PfSBP1'.
Sign Up to like & getrecommendations! Published in 2018 at "Pathogens and disease"
DOI: 10.1093/femspd/fty090
Abstract: Plasmodium falciparum (Pf) proteins exported to infected erythrocytes are key effectors of malaria pathogenesis. These include the PfEMP1 (Pf erythrocyte membrane protein 1) protein family that affects malaria-related mortality through cytoadhesion and parasite immune evasion.… read more here.
Keywords: protein; plasmodium falciparum; pfsbp1; pfemp1 ... See more keywords
From genomic to LC-MS/MS evidence: Analysis of PfEMP1 in Benin malaria cases
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0218012
Abstract: Background PfEMP1 is the major protein from parasitic origin involved in the pathophysiology of severe malaria, and PfEMP1 domain subtypes are associated with the infection outcome. In addition, PfEMP1 variability is endless and current publicly… read more here.
Keywords: protein; malaria; analysis; pfemp1 ... See more keywords
Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202153641
Abstract: Plasmodium falciparum, the deadliest form of human malaria, remains one of the major threats to human health in endemic regions. Its virulence is attributed to its ability to modify infected red blood cells (iRBC) to… read more here.
Keywords: implicated cerebral; pfemp1 variants; neutrophils impose; cerebral malaria ... See more keywords
Interaction Analysis of a Plasmodium falciparum PHISTa-like Protein and PfEMP1 Proteins
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.611190
Abstract: Plasmodium falciparum extensively remodels host cells by translocating numerous proteins into the cytoplasm of red blood cells (RBCs) after invasion. Among these exported proteins, members of the Plasmodium helical interspersed subtelomeric (PHIST) family are crucial… read more here.
Keywords: phista like; protein pfemp1; falciparum; pfemp1 ... See more keywords