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   Articles with "pfhrp2 pfhrp3" as a keyword



A novel multiplex qPCR assay for detection of Plasmodium falciparum with histidine-rich protein 2 and 3 (pfhrp2 and pfhrp3) deletions in polyclonal infections

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recommendations! Published in 2020 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2020.102757

Abstract: Background Many health facilities in malaria endemic countries are dependent on Rapid diagnostic tests (RDTs) for diagnosis and some National Health Service (NHS) hospitals without expert microscopists rely on them for diagnosis out of hours.… read more here.

Keywords: protein; pfhrp2 pfhrp3; pfhrp3 deletions; qpcr assay ... See more keywords

Plasmodium falciparum histidine-rich protein (PfHRP2 and 3) diversity in Western and Coastal Kenya

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-018-38175-1

Abstract: Plasmodium falciparum histidine-rich proteins 2 (PfHRP2) based RDTs are advocated in falciparum malaria-endemic regions, particularly when quality microscopy is not available. However, diversity and any deletion in the pfhrp2 and pfhrp3 genes can affect the… read more here.

Keywords: pfhrp3; amino acid; pfhrp2 pfhrp3; plasmodium falciparum ... See more keywords
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Systematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in Plasmodium falciparum populations in Africa: review of published studies 2010–2019

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recommendations! Published in 2019 at "Malaria Journal"

DOI: 10.1186/s12936-019-2987-4

Abstract: BackgroundMalaria rapid diagnostic tests based on histidine-rich protein-2 have played a vital role in improving malaria case management and surveillance particularly in Africa, where Plasmodium falciparum is predominant. However, their usefulness has been threatened by… read more here.

Keywords: pfhrp2 pfhrp3; deletion; gene deletion; review ... See more keywords
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Molecular surveillance reveals the presence of pfhrp2 and pfhrp3 gene deletions in Plasmodium falciparum parasite populations in Uganda, 2017–2019

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recommendations! Published in 2020 at "Malaria Journal"

DOI: 10.1186/s12936-020-03362-x

Abstract: Histidine-rich protein-2 (HRP2)-based rapid diagnostic tests (RDTs) are the only RDTs recommended for malaria diagnosis in Uganda. However, the emergence of Plasmodium falciparum histidine rich protein 2 and 3 (pfhrp2 and pfhrp3) gene deletions threatens… read more here.

Keywords: gene deletions; pfhrp2 pfhrp3; presence; gene ... See more keywords

Limited threat of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletion to the utility of HRP2-based malaria RDTs in Northern Uganda

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recommendations! Published in 2024 at "Malaria Journal"

DOI: 10.1186/s12936-023-04830-w

Abstract: Background Rapid diagnostic tests (RDTs) that detect Plasmodium falciparum histidine-rich protein-2 (PfHRP2) are exclusively deployed in Uganda, but deletion of the pfhrp2/3 target gene threatens their usefulness as malaria diagnosis and surveillance tools. Methods A… read more here.

Keywords: pfhrp2; plasmodium; pfhrp3 gene; gene ... See more keywords

First report of pfhrp2 and pfhrp3 gene deletions compromising HRP2-based malaria rapid diagnostic tests in Malawi

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recommendations! Published in 2025 at "Infectious Diseases of Poverty"

DOI: 10.1186/s40249-025-01368-8

Abstract: Histidine Rich Protein 2-based rapid diagnostic tests (HRP2-based RDTs) are widely used for malaria diagnosis in Malawi, but their accuracy may be compromised by Plasmodium falciparum parasites lacking the P. falciparum histidine rich protein 2… read more here.

Keywords: pfhrp2; gene deletions; hrp2 based; pfhrp3 gene ... See more keywords

Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions and Relatedness to Other Global Isolates, Djibouti, 2019–2020

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recommendations! Published in 2022 at "Emerging Infectious Diseases"

DOI: 10.3201/eid2810.220695

Abstract: Deletions of pfhrp2 and paralogue pfhrp3 (pfhrp2/3) genes threaten Plasmodium falciparum diagnosis by rapid diagnostic test. We examined 1,002 samples from suspected malaria patients in Djibouti City, Djibouti, to investigate pfhrp2/3 deletions. We performed assays… read more here.

Keywords: pfhrp2; plasmodium falciparum; gene deletions; pfhrp2 pfhrp3 ... See more keywords

Genomic Deletion of PfHRP2 and PfHRP3 in Plasmodium falciparum Strains, Ethiopia, 2009

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recommendations! Published in 2025 at "Emerging Infectious Diseases"

DOI: 10.3201/eid3107.241676

Abstract: Plasmodium falciparum strains lacking P. falciparum histidine-rich protein 2 (PfHRP2) and PfHRP3 threaten malaria rapid test reliability. We show that pfhrp2/pfhrp3–deleted parasites circulated in Ethiopia as early as 2009, before widespread PfHRP2-based rapid test use,… read more here.

Keywords: plasmodium falciparum; falciparum strains; pfhrp3; pfhrp2 pfhrp3 ... See more keywords