Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents
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DOI: 10.1073/pnas.2017749118
Abstract: Significance There is an urgent need for alternative antimalarials with the emergence of artemisinin-resistant malaria parasites. Blocking sugar uptake in Plasmodium falciparum by selectively inhibiting the hexose transporter P. falciparum hexose transporter 1 (PfHT1) kills… read more here.
Keywords: orthosteric allosteric; resistant malaria; falciparum; hexose transporter ... See more keywords