Long intergenic non-protein coding RNA 115 (LINC00115) aggravates retinoblastoma progression by targeting microRNA miR-489-3p that downregulates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2)
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2037362
Abstract: ABSTRACT Long non-coding RNAs (lncRNAs) are key regulators of cancer. However, the role of long intergenic non-protein coding RNA 115 (LINC00115) in the regulation of retinoblastoma (RB) has not yet been studied. The expression levels… read more here.
Keywords: intergenic non; non protein; long intergenic; pfkfb2 ... See more keywords
PFKFB2 inhibits ferroptosis in myocardial ischemia/reperfusion injury through AMPK activation.
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DOI: 10.1097/fjc.0000000000001437
Abstract: ABSTRACT 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) is a key regulator of glycolytic enzyme. This study identified if PFKFB2 can regulate myocardial ferroptosis in ischemia/reperfusion (I/R) injury. Mice myocardial (I/R) injury and H9c2 cells oxygen-glucose deprivation/reperfusion (OGD/R)… read more here.
Keywords: reperfusion injury; pfkfb2; reperfusion; pfkfb2 inhibits ... See more keywords
Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney
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DOI: 10.1371/journal.pone.0280792
Abstract: The anti-fibrotic effect of metformin has been widely demonstrated. Fibrosis in the kidney after injury is associated with reduced expression of genes involved in both fatty acid and glycolytic energy metabolism. We have previously reported… read more here.
Keywords: pfkfb2; effect metformin; fibrotic effect; metformin ... See more keywords