The Glycolytic Enzyme PFKFB3 Controls TNF-α-Induced Endothelial Proinflammatory Responses
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0880-x
Abstract: Endothelial cells play an important role in health and a variety of diseases. Recent evidences show that endothelial cells rely on glycolysis rather than on oxidative phosphorylation to generate energy to support cellular functions such… read more here.
Keywords: pfkfb3; tnf induced; endothelial cells; enzyme pfkfb3 ... See more keywords
The potential utility of PFKFB3 as a therapeutic target
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2018.1498082
Abstract: ABSTRACT Introduction: It has been known for over half a century that tumors exhibit an increased demand for nutrients to fuel their rapid proliferation. Interest in targeting cancer metabolism to treat the disease has been… read more here.
Keywords: pfkfb3; potential utility; metabolism; target ... See more keywords
Myeloma-derived IL-32γ induced PD-L1 expression in macrophages facilitates immune escape via the PFKFB3-JAK1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2057837
Abstract: ABSTRACT Multiple myeloma (MM) is characterized by an accumulation of monoclonal plasma cells within the bone marrow (BM). Macrophages are an abundant component of myeloma BM microenvironment and support survival of the malignant cells and… read more here.
Keywords: myeloma; expression; jak1 axis; expression macrophages ... See more keywords
Gene‐dosage effect of Pfkfb3 on monocyte/macrophage biology in atherosclerosis
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DOI: 10.1111/bph.15926
Abstract: Macrophage‐rich atherosclerotic arteries are highly active in glycolysis. PFKFB3, a key glycolytic enzyme, has emerged as a potential therapeutic target in atherosclerosis. Small‐molecule inhibitors of PFKFB3, such as 3PO and PFK158, have demonstrated efficacy in… read more here.
Keywords: dosage effect; atherosclerosis; gene dosage; macrophage ... See more keywords
PFKFB3 Increases IL-1β and TNF-α in Intestinal Epithelial Cells to Promote Tumorigenesis in Colitis-Associated Colorectal Cancer
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DOI: 10.1155/2022/6367437
Abstract: Colorectal cancer (CRC) is significantly correlated with inflammatory bowel disease, which usually manifests as chronic relapsing-remitting colitis. Phosphofructo-2-kinase/fructose-2,6-biophosphatase 3 (PFKFB3) can catalyze to produce fructose-2,6-bisphosphate and function as an oncogene. In this study, we revealed… read more here.
Keywords: colitis associated; colitis; colorectal cancer; epithelial cells ... See more keywords
p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis
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DOI: 10.1158/0008-5472.can-19-3281
Abstract: These findings show that p38γ links KRAS oncogene signaling and the Warburg effect through PFKBF3 and Glut2 to promote pancreatic tumorigenesis, which can be disrupted via inhibition of p38γ and PFKFB3. KRAS is mutated in… read more here.
Keywords: pfkfb3; tumorigenesis; aerobic glycolysis; p38 ... See more keywords
Protective Effect of Mesenchymal Stem Cells on Isolated Islets Survival and Against Hypoxia Associated With the HIF-1α/PFKFB3 Pathway
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DOI: 10.1177/09636897211073127
Abstract: Islets have a high demand for oxygen and most of them will die of hypoxia injury before and after transplantation. Hypoxic damage is one of the key factors associated with islet graft dysfunction. Mesenchymal stem… read more here.
Keywords: hif pfkfb3; effect; mesenchymal stem; mscs ... See more keywords
A High-Throughput Screening Triage Workflow to Authenticate a Novel Series of PFKFB3 Inhibitors
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DOI: 10.1177/2472555217732289
Abstract: A high-throughput screen (HTS) of human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) resulted in several series of compounds with the potential for further optimization. Informatics was used to identify active chemotypes with lead-like profiles and remove compounds that… read more here.
Keywords: pfkfb3; series compounds; high throughput; series ... See more keywords
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
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DOI: 10.2210/pdb6etj/pdb
Abstract: The glycolytic PFKFB3 enzyme is widely overexpressed in cancer cells and an emerging anti-cancer target. Here, we identify PFKFB3 as a critical factor in homologous recombination (HR) repair of DNA double-strand breaks. PFKFB3 rapidly relocates… read more here.
Keywords: pfkfb3; homologous recombination; cancer cells; cancer ... See more keywords
The glycolytic enzyme PFKFB3 determines bone marrow endothelial progenitor cell damage after chemotherapy and irradiation
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2021.279756
Abstract: Bone marrow (BM) endothelial progenitor cell (EPC) damage of unknown mechanism delays the repair of endothelial cells (EC) and recovery of hematopoiesis after chemo-radiotherapy. We found increased levels of the glycolytic enzyme PFKFB3 in the… read more here.
Keywords: cell; damage; bone marrow; expression ... See more keywords
Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.695684
Abstract: Background The protein 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a key stimulator of glycolytic flux. Systemic, partial PFKFB3 inhibition previously decreased total plaque burden and increased plaque stability. However, it is unclear which cell type conferred these positive… read more here.
Keywords: pfkfb3; myeloid cells; inhibition; phosphofructo kinase ... See more keywords