6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells
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DOI: 10.1038/onc.2016.477
Abstract: The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 (PFKFB4) controls metabolic flux through allosteric regulation of glycolysis. Here we show that p53 regulates the expression of PFKFB4 and that p53-deficient cancer cells are highly dependent on the function of… read more here.
Keywords: deficient cancer; pfkfb4; cancer cells; cancer ... See more keywords
Loss of PFKFB4 induces cell cycle arrest and glucose metabolism inhibition by inactivating MEK/ERK/c-Myc pathway in cervical cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Obstetrics and Gynaecology"
DOI: 10.1080/01443615.2022.2062225
Abstract: Abstract 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) was reported to be necessary for tumour growth in several cancers. However, the function of PFKFB4 in cervical cancer has not been clearly elucidated. Bioinformatics analysis was applied to detect the… read more here.
Keywords: cervical cancer; cancer; glucose metabolism; pfkfb4 ... See more keywords
Abstract 1906: PFKFB4, much more than just a glycolytic gene
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1906
Abstract: Glioblastoma is one of the most aggressive primary brain tumors in adults, with a dismal median overall survival of only 14 months after diagnosis. Glioblastoma stem-like cells (GSCs) are particularly resistant to current therapies, capable… read more here.
Keywords: protein; much glycolytic; pfkfb4; glycolytic gene ... See more keywords
Abstract 461: Targeting glucose metabolism in lung cancer
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DOI: 10.1158/1538-7445.am2023-461
Abstract: Positron emission tomographic studies with 2-18F-fluoro-deoxy-glucose (FDG-PET) consistently demonstrate that non-small cell lung cancers (NSCLC) take up significantly more glucose than normal lung. NSCLCs preferentially utilize glucose to support their rapid growth- a phenotype driven… read more here.
Keywords: targeting glucose; lung cancer; lung; glucose metabolism ... See more keywords
The metabolic role of PFKFB4 in androgen-independent growth in vitro and PFKFB4 expression in human prostate cancer tissue
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DOI: 10.1186/s12894-020-00635-0
Abstract: Background It is well known that androgen-deprivation therapy (ADT) can inevitably drive prostate cancer (PCa) cells into a castration-resistant state. According to the “Warburg effect”, the metabolism of aggressive tumor cells increases significantly. The growth… read more here.
Keywords: lncap cells; pfkfb4 expression; tissue; pfkfb4 ... See more keywords
Effect of PFKFB4 on the Prognosis and Immune Regulation of NSCLC and Its Mechanism
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DOI: 10.2147/ijgm.s369126
Abstract: Background NSCLC (non-small cell lung cancer) has become the malignancy with the highest incidence and mortality rate worldwide. Fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is a key regulator of glycolysis with both kinase and phosphatase activities. The… read more here.
Keywords: cell; prognosis; pfkfb4 expression; pfkfb4 ... See more keywords
Long Non-Coding RNA LINC01572 Promotes Hepatocellular Carcinoma Progression via Sponging miR-195-5p to Enhance PFKFB4-Mediated Glycolysis and PI3K/AKT Activation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.783088
Abstract: Background: Accumulating evidence indicates that type 2 diabetes mellitus (T2DM) is a risk factor for hepatocellular carcinoma (HCC), and T2DM-associated HCC represents a common type of HCC cases. We herein identify an lncRNA LINC01572 that… read more here.
Keywords: hcc; linc01572; pfkfb4; pi3k akt ... See more keywords
PFKFB4 promotes angiogenesis via IL-6/STAT5A/P-STAT5 signaling in breast cancer
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DOI: 10.7150/jca.66773
Abstract: Breast cancer has become the most newly-diagnosed cancer and the 5th leading cause of cancer death worldwide. The 5-year survival rate of breast cancer is about 90%. However, the 5-year survival rate drops to read more here.
Keywords: cancer; angiogenesis via; breast cancer; signaling breast ... See more keywords