Abstract 5023: PFKP contributes to ovarian cancer metastasis, stemness and anchorage-independent growth via α5 integrin and ERK/MMP9 signaling
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5023
Abstract: Background: Ovarian cancer is one of the most aggressive malignancies threatening women’s health worldwide. Its high mortality rate is largely due to symptoms not appearing until late in the disease, usually after the cancer has… read more here.
Keywords: ovarian cancer; pfkp; mmp9; cancer ... See more keywords
The Platelet Isoform of Phosphofructokinase in Acute Myeloid Leukemia: Clinical Relevance and Prognostic Implication
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DOI: 10.1182/blood-2018-99-113786
Abstract: Background: Phosphofructokinase (PFK), a key enzyme of the glycolytic pathway, has L (liver), M (muscle), and P (platelet) isoforms with different tissue distributions. The Platelet Isoform of PFK (PFKP) plays an important role in regulating… read more here.
Keywords: pfkp; group; expression; rate ... See more keywords
Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells
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DOI: 10.15252/embr.202255683
Abstract: Unveiling the principles governing embryonic stem cell (ESC) differentiation into specific lineages is critical for understanding embryonic development and for stem cell applications in regenerative medicine. Here, we establish an intersection between LIF‐Stat3 signaling that… read more here.
Keywords: protein kinase; embryonic stem; pfkp; differentiation ... See more keywords
PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease
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DOI: 10.3389/fendo.2021.797025
Abstract: Background Glycolysis dysfunction is an important pathogenesis of podocyte injury in diabetic kidney disease (DKD). Foot process fusion of podocytes and increased albuminuria are markers of early DKD. Moreover, cytoskeletal remodeling has been found to… read more here.
Keywords: fusion podocytes; cytoskeletal remodeling; foot process; process fusion ... See more keywords
Wnt signaling promotes tumor development in part through phosphofructokinase 1 platelet isoform upregulation.
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DOI: 10.3892/or.2021.8185
Abstract: The activation of Wnt signaling has been detected in various types of human cancer and has been shown to be associated with cancer development. In the present study, it was revealed that Wnt signaling induced… read more here.
Keywords: wnt signaling; platelet isoform; pfkp; tumor development ... See more keywords