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   Articles with "pfkp" as a keyword



Mitoquinol improves phagocytosis and glycolysis in ethanol-exposed macrophages via HIF-1α-PFKP axis.

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recommendations! Published in 2025 at "Journal of immunology"

DOI: 10.1093/jimmun/vkaf078

Abstract: Alcohol use disorder increases sepsis mortality. Acute ethanol exposure impairs pathogen clearance in the macrophages via dampened glycolysis and phagocytosis, exaggerates oxidative stress, and regulates the function of the hypoxia-regulating factor 1α (HIF-1α), a master… read more here.

Keywords: ethanol exposed; pfkp; ethanol; phagocytosis ... See more keywords

Abstract 5023: PFKP contributes to ovarian cancer metastasis, stemness and anchorage-independent growth via α5 integrin and ERK/MMP9 signaling

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-5023

Abstract: Background: Ovarian cancer is one of the most aggressive malignancies threatening women’s health worldwide. Its high mortality rate is largely due to symptoms not appearing until late in the disease, usually after the cancer has… read more here.

Keywords: ovarian cancer; pfkp; mmp9; cancer ... See more keywords

The Platelet Isoform of Phosphofructokinase in Acute Myeloid Leukemia: Clinical Relevance and Prognostic Implication

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recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-113786

Abstract: Background: Phosphofructokinase (PFK), a key enzyme of the glycolytic pathway, has L (liver), M (muscle), and P (platelet) isoforms with different tissue distributions. The Platelet Isoform of PFK (PFKP) plays an important role in regulating… read more here.

Keywords: pfkp; group; expression; rate ... See more keywords

PKP1 promotes lung cancer by modulating energy metabolism through stabilization of PFKP

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recommendations! Published in 2025 at "Biomarker Research"

DOI: 10.1186/s40364-025-00815-w

Abstract: Lung cancer is the leading cause of cancer-related deaths worldwide, with lung squamous cell carcinoma (LUSC) lacking effective targeted therapies. Recent studies have identified Plakophilin-1 (PKP1) as one of the most differentially overexpressed genes in… read more here.

Keywords: pkp1 promotes; pkp1; cancer; pfkp ... See more keywords
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Novel cuproptosis-related genes C1QBP and PFKP identified as prognostic and therapeutic targets in lung adenocarcinoma

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recommendations! Published in 2025 at "Open Life Sciences"

DOI: 10.1515/biol-2025-1142

Abstract: Abstract Excessive intracellular copper accumulation triggers cuproptosis, a novel regulated cell death process with therapeutic potential. Analyzing 566 The Cancer Genome Atlas samples alongside lung adenocarcinoma (LUAD)-specific microarray and single-cell sequencing data, we identified 109… read more here.

Keywords: c1qbp pfkp; pfkp; lung adenocarcinoma; genes c1qbp ... See more keywords

Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells

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recommendations! Published in 2023 at "EMBO reports"

DOI: 10.15252/embr.202255683

Abstract: Unveiling the principles governing embryonic stem cell (ESC) differentiation into specific lineages is critical for understanding embryonic development and for stem cell applications in regenerative medicine. Here, we establish an intersection between LIF‐Stat3 signaling that… read more here.

Keywords: protein kinase; embryonic stem; pfkp; differentiation ... See more keywords

PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease

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recommendations! Published in 2022 at "Frontiers in Endocrinology"

DOI: 10.3389/fendo.2021.797025

Abstract: Background Glycolysis dysfunction is an important pathogenesis of podocyte injury in diabetic kidney disease (DKD). Foot process fusion of podocytes and increased albuminuria are markers of early DKD. Moreover, cytoskeletal remodeling has been found to… read more here.

Keywords: fusion podocytes; cytoskeletal remodeling; foot process; process fusion ... See more keywords

Wnt signaling promotes tumor development in part through phosphofructokinase 1 platelet isoform upregulation.

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recommendations! Published in 2021 at "Oncology reports"

DOI: 10.3892/or.2021.8185

Abstract: The activation of Wnt signaling has been detected in various types of human cancer and has been shown to be associated with cancer development. In the present study, it was revealed that Wnt signaling induced… read more here.

Keywords: wnt signaling; platelet isoform; pfkp; tumor development ... See more keywords

PFKP silencing suppresses tumor growth via the AXL-MET axis

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recommendations! Published in 2024 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.100525

Abstract: PFKP (Phosphofructokinase, Platelet Type isoform), as an essential metabolic enzyme, contributes to the high glycolysis rates seen in cancers while its role in oncogenic pathways, especially from a non-metabolic aspect, is not fully understood. We… read more here.

Keywords: pfkp; met axis; axl met; pfkp silencing ... See more keywords