Change in molecular weight due to important pfatp6 and pfmdr1 polymorphisms and susceptibility to antimalarial drug: Possible role of epigenetic phenomenon
Sign Up to like & getrecommendations! Published in 2017 at "Asian pacific Journal of Tropical Biomedicine"
DOI: 10.1016/j.apjtb.2016.12.006
Abstract: Abstract Malaria is an important tropical mosquito borne infection. It is still the present global public health issue. The management of malaria requires antimalarial drugs. The resistance to antimalarial drugs is a very big problem.… read more here.
Keywords: pfatp6; change; antimalarial drug; susceptibility antimalarial ... See more keywords
Polymorphism analysis of pfmdr1 gene in Plasmodium falciparum isolates 11 years post-adoption of artemisinin-based combination therapy in Saudi Arabia
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DOI: 10.1038/s41598-021-04450-x
Abstract: A total of 227 Plasmodium falciparum isolates from Jazan region, southwestern Saudi Arabia were amplified for the P. falciparum multi-drug resistance 1 ( pfmdr1 ) gene to detect point mutations 11 years after the introduction of… read more here.
Keywords: falciparum; pfmdr1; saudi arabia; plasmodium falciparum ... See more keywords
Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport
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DOI: 10.1128/mbio.02093-20
Abstract: Global efforts to eliminate malaria depend on the continued success of artemisinin-based combination therapies (ACTs) that target Plasmodium asexual blood-stage parasites. Resistance to ACTs, however, has emerged, creating the need to define the underlying mechanisms.… read more here.
Keywords: pfmdr1; plasmodium; southeast asia; resistance ... See more keywords
Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976–78
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DOI: 10.1186/s12936-017-1747-6
Abstract: BackgroundTo assess the effect on malaria prevalence, village specific monthly administrations of pyrimethamine, chlorproguanil, chloroquine or placebo were given to children in four previously treatment-naïve Liberian villages, 1976–78. Plasmodium falciparum in vivo resistance developed to… read more here.
Keywords: village; treatment; previously treatment; plasmodium falciparum ... See more keywords
Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya
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DOI: 10.1186/s12936-018-2534-8
Abstract: BackgroundThere are concerns that resistance to artemisinin-based combination therapy might emerge in Kenya and sub-Saharan Africa (SSA) in the same pattern as was with chloroquine and sulfadoxine–pyrimethamine. Single nucleotide polymorphisms (SNPs) in critical alleles of… read more here.
Keywords: drug resistance; genetic lineages; pfmdr1 gene; resistance ... See more keywords
Prevalence of Mutations in the Pfdhfr, Pfdhps, and Pfmdr1 Genes of Malarial Parasites Isolated from Symptomatic Patients in Dogondoutchi, Niger
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DOI: 10.3390/tropicalmed7080155
Abstract: The effectiveness of artemisinin-based combination therapies (ACTs) depends not only on that of artemisinin but also on that of partner molecules. This study aims to evaluate the prevalence of mutations in the Pfdhfr, Pfdhps, and… read more here.
Keywords: prevalence mutations; pfdhps pfmdr1; mutations pfdhfr; pfmdr1 ... See more keywords