Trend of N86Y and Y184F Mutations in Pfmdr1 Gene in Children Under Seasonal Malaria Chemoprevention Coverage in Nanoro, Burkina Faso
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DOI: 10.1007/s11686-024-00923-x
Abstract: Seasonal malaria chemoprevention (SMC) is an effective malaria preventive intervention in sub-Sahara Africa. However, as with any other drug-based intervention, the large-scale deployment of this strategy could lead to Amodiaquine plus Sulfadoxine-Pyrimethamine (AQSP) drug pressure… read more here.
Keywords: malaria chemoprevention; pfmdr1 gene; burkina faso; seasonal malaria ... See more keywords
Molecular investigation of the Pfmdr1 gene of Plasmodium falciparum isolates in Henan Province imported from Africa
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DOI: 10.1017/s0031182018001609
Abstract: Abstract Efficacious antimalarial drugs are important for malaria control and elimination, and continuous monitoring of their efficacy is essential. The prevalence and distribution of Pfmdr1 were evaluated in African migrant workers in Henan Province. Among… read more here.
Keywords: molecular investigation; henan province; province; pfmdr1 gene ... See more keywords
Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya
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DOI: 10.1186/s12936-018-2534-8
Abstract: BackgroundThere are concerns that resistance to artemisinin-based combination therapy might emerge in Kenya and sub-Saharan Africa (SSA) in the same pattern as was with chloroquine and sulfadoxine–pyrimethamine. Single nucleotide polymorphisms (SNPs) in critical alleles of… read more here.
Keywords: drug resistance; genetic lineages; pfmdr1 gene; resistance ... See more keywords