Profilin-1 is dysregulated in endometroid (type I) endometrial cancer promoting cell proliferation and inhibiting pro-inflammatory cytokine production.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.123
Abstract: Endometrial cancer (EC) is the most common gynaecological malignancy. Alarmingly its incidence and mortality rate is increasing particularly in younger women of reproductive age. Despite this, there are limited treatment options for EC. Profilin-1 (PFN1)… read more here.
Keywords: pfn1; proliferation; endometrial epithelial; cancer ... See more keywords
Visualizing molecules of functional human profilin
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2021.09.01.458557
Abstract: Profilin-1 (PFN1) is a cytoskeletal protein that regulates the dynamics of actin and microtubule assembly. Thus, PFN1 is essential for the normal division, motility, and morphology of cells. Unfortunately, conventional fusion and direct labeling strategies… read more here.
Keywords: molecules functional; biochemical assays; pfn1; visualizing molecules ... See more keywords
Abstract 4584: Genetic disruption of vascular endothelial profilin-1 impacts tumor microenvironment supressing tumorigenicity of renal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4584
Abstract: Renal cell carcinoma (RCC) is estimated to result in 79,000 new cases and 13,920 deaths in 2022. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC and is characterized by a… read more here.
Keywords: cell; pfn1; tumor microenvironment; tumor ... See more keywords
Evaluation of profilin 1 as a biomarker in myocardial infarction.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202008_22497
Abstract: OBJECTIVE Profilin 1 (Pfn1) is likely to be involved in atherogenesis and myocardial infarction (MI). Clinical data on this subject are very limited. The aim of this study was to search for associations between serum… read more here.
Keywords: profilin; pfn1; timi flow; myocardial infarction ... See more keywords
Upregulated Expression of Profilin1 on Dendritic Cells in Patients With Severe Aplastic Anemia
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.631954
Abstract: Severe aplastic anemia (SAA) is a life-threatening form of bone marrow failure that is associated with very high mortality. Dendritic cells (DCs) are antigen presenting cells (APCs) with powerful movement ability, which is an important… read more here.
Keywords: aplastic anemia; pfn1; expression profilin1; dendritic cells ... See more keywords
Profilin 1 Induces Tumor Metastasis by Promoting Microvesicle Secretion Through the ROCK 1/p-MLC Pathway in Non-Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.890891
Abstract: Profilin 1 (PFN1), an actin-binding protein, plays contrasting roles in the metastasis of several cancers; however, its role in non-small cell lung cancer (NSCLC) metastasis remains unclear. Here, PFN1 expression was upregulated in metastatic NSCLC… read more here.
Keywords: metastasis; non small; pfn1; small cell ... See more keywords
The Amyotrophic Lateral Sclerosis M114T PFN1 Mutation Deregulates Alternative Autophagy Pathways and Mitochondrial Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105694
Abstract: Mutations in profilin 1 (PFN1) have been identified in rare familial cases of Amyotrophic Lateral Sclerosis (ALS). PFN1 is involved in multiple pathways that could intervene in ALS pathology. However, the specific pathogenic role of… read more here.
Keywords: autophagy pathways; pfn1 mutations; pfn1; lateral sclerosis ... See more keywords
A pilot study of the relative number of circulating tumor cells and leukocytes containing actin-binding proteins in head and neck cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomedical Research"
DOI: 10.7555/jbr.36.20220182
Abstract: Circulating tumor cells (CTCs) play an important role in tumor metastases, which is positively correlated with an increased risk of death. Actin-binding proteins, including cofilin (CFL1), profilin 1 (PFN1), and adenylate cyclase-associated protein 1 (CAP1),… read more here.
Keywords: actin binding; pfn1; number; binding proteins ... See more keywords