Inhibition of the assembly of Plasmodium Hsp70-1 and Hsp40 complex blocks DNA replication by destabilizing ribonucleotide reductase subunit-2
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DOI: 10.1128/mbio.02129-25
Abstract: ABSTRACT Plasmodium falciparum undergoes endoreduplication, in which its nuclear, mitochondrial, and apicoplast genomes are replicated multiple times without cytokinesis,; enabling replication as a promising target for arresting parasite growth and pathogenicity. Previously, it was reported… read more here.
Keywords: replication; inhibition; ribonucleotide reductase; pfr2 ... See more keywords