Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins
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DOI: 10.1038/s42003-020-01123-9
Abstract: Proteins Pfs230 and Pfs48/45 are Plasmodium falciparum transmission-blocking (TB) vaccine candidates that form a membrane-bound protein complex on gametes. The biological role of Pfs230 or the Pfs230-Pfs48/45 complex remains poorly understood. Here, we present the… read more here.
Keywords: pfs230; blocking vaccine; pfs230 pfs48; transmission blocking ... See more keywords
Particle-based, Pfs230 and Pfs25 immunization is effective, but not improved by duplexing at fixed total antigen dose
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DOI: 10.1186/s12936-020-03368-5
Abstract: Background The Plasmodium falciparum sexual-stage surface proteins Pfs25 and Pfs230 are antigen candidates for a malaria transmission-blocking vaccine (TBV), and have been widely investigated as such. It is not clear whether simultaneously presenting these two… read more here.
Keywords: pfs230; immunization; antigen; pfs25 ... See more keywords
Development and Qualification of an Antigen Integrity Assay for a Plasmodium falciparum Malaria Transmission Blocking Vaccine Candidate, Pfs230
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DOI: 10.3390/vaccines10101628
Abstract: During development of a subunit vaccine, monitoring integrity of the recombinant protein for process development and quality control is critical. Pfs230 is a leading malaria transmission blocking vaccine candidate and the first to reach a… read more here.
Keywords: blocking vaccine; development; pfs230; integrity ... See more keywords