Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins
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DOI: 10.1038/s42003-020-01123-9
Abstract: Proteins Pfs230 and Pfs48/45 are Plasmodium falciparum transmission-blocking (TB) vaccine candidates that form a membrane-bound protein complex on gametes. The biological role of Pfs230 or the Pfs230-Pfs48/45 complex remains poorly understood. Here, we present the… read more here.
Keywords: pfs230; blocking vaccine; pfs230 pfs48; transmission blocking ... See more keywords
Pfs230 and Pfs48/45 Fusion Proteins Elicit Strong Transmission-Blocking Antibody Responses Against Plasmodium falciparum
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DOI: 10.3389/fimmu.2019.01256
Abstract: The Plasmodium falciparum Pfs230 and Pfs48/45 proteins are expressed during transmission from man to mosquito and are leading candidates for a malaria transmission blocking vaccine. Individually they generate transmission blocking (TB) antibodies in rodent models.… read more here.
Keywords: pfs230 pfs48; transmission; plasmodium falciparum; transmission blocking ... See more keywords
Immune Responses to Gametocyte Antigens in a Malaria Endemic Population—The African falciparum Context: A Systematic Review and Meta-Analysis
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DOI: 10.3389/fimmu.2019.02480
Abstract: Background: Malaria elimination remains a priority research agenda with the need for interventions that reduce and/or block malaria transmission from humans to mosquitoes. Transmission-blocking vaccines (TBVs) are in development, most of which target the transmission… read more here.
Keywords: pfs230 pfs48; analysis; gametocyte antigens; immune responses ... See more keywords