PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP/AMPK/CEBPB pathway
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13259
Abstract: Phosphoglycerate mutase 1 (PGAM1) is a crucial glycolytic enzyme, and its expression status has been confirmed to be associated with tumor progression and metastasis. However, the precise role and other biological functions of PGAM1 remain… read more here.
Keywords: pgam1; progression; ampk cebpb; expression ... See more keywords
Phosphoglycerate Mutase 1 Promotes Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus by Facilitating the Phosphorylation of cAMP Response Element-Binding Protein
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2678-5
Abstract: In a previous study, we observed a significant increase in phosphoglycerate mutase 1 (PGAM1) levels after pyridoxine treatment. In the present study, we investigated the effects of PGAM1 on novel object recognition, cell proliferation, and… read more here.
Keywords: control; dentate gyrus; group; tat pgam1 ... See more keywords
Phosphoglycerate mutase 1 reduces neuronal damage in the hippocampus following ischemia/reperfusion through the facilitation of energy utilization
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2019.104631
Abstract: In a previous study, we observed the effect of phosphoglycerate mutase 1 (PGAM1) on proliferating cells and neuroblasts in the subgranular zone of mouse dentate gyrus. In the present study, we examined the roles of… read more here.
Keywords: ischemia reperfusion; tat pgam1; pgam1; damage ... See more keywords
Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity
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DOI: 10.1038/onc.2016.446
Abstract: Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that coordinates glycolysis and biosynthesis to promote cancer growth via its metabolic activity. Here, we report the discovery of a non-metabolic function of PGAM1 in promoting cancer… read more here.
Keywords: cancer; cell migration; pgam1; metabolic activity ... See more keywords
NAT10 promotes glycolysis and cell stemness of ovarian cancer cells via ac4C acetylation of PGAM1 mRNA
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-22902-6
Abstract: Ovarian cancer represents one of the most prevalent gynecological malignancies with a poor prognosis. Targeting glycolytic pathways has emerged as a novel cancer therapeutic strategy. N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) modification plays a regulatory role… read more here.
Keywords: cancer; cancer cells; ovarian cancer; pgam1 ... See more keywords
MicroRNA‐324‐3p inhibits osteosarcoma progression by suppressing PGAM1‐mediated aerobic glycolysis
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DOI: 10.1111/cas.15779
Abstract: Osteosarcoma (OS) is the most common primary malignant neoplasm of the bone. Recent studies have indicated that the inhibitory effects of microRNA (miR)‐324‐3p could affect the development of numerous cancers. However, its biological roles and… read more here.
Keywords: pgam1; progression; microrna 324; aerobic glycolysis ... See more keywords
Abstract 1519: Therapeutic targeting of phosphoglycerate mutase 1 disrupts cellular redox balance and promotes DNA damage in head and neck cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1519
Abstract: Head and neck squamous cell carcinomas (HNSCCs) are extremely aggressive cancers that exhibit notable metabolic reprogramming and resistance to therapy. Phosphoglycerate mutase 1 (PGAM1), a glycolytic enzyme, has emerged as an important regulator of cancer… read more here.
Keywords: cancer; head neck; cell; pgam1 ... See more keywords
LncRNA SPINT1-AS1 enhances the Warburg effect and promotes the progression of osteosarcoma via the miR-135b-5p/PGAM1 axis
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DOI: 10.1186/s12935-025-03761-7
Abstract: Osteosarcoma (OS) is a malignant bone tumor that originates from interstitial tissues and affects the health of children and adolescents. Long noncoding RNAs (lncRNAs) are an intriguing category of widely distributed endogenous RNAs involved in… read more here.
Keywords: progression; lncrna spint1; pgam1; spint1 as1 ... See more keywords
Phosphoglycerate mutase 1 is highly expressed in C6 glioma cells and human astrocytoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.8477
Abstract: The aim of the present study was to examine the expression of phosphoglycerate mutase 1 (PGAM1) in astrocytomas, and to investigate its role in the progression of astrocytomas. The expression of PGAM1 mRNA in rat… read more here.
Keywords: expression pgam1; glioma; phosphoglycerate mutase; glioma cells ... See more keywords