Leucine-Dependent SLC7A5-PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202518359
Abstract: The residual risks of advanced atherosclerosis remain substantial despite current preventive strategies and pharmacotherapy. Circulating branched-chain amino acids are biomarkers of cardiovascular disease risk. However, the mechanism of leucine in atherosclerosis progression remains unclear. Leucine… read more here.
Keywords: mitochondrial function; pgam5; function; atherosclerosis ... See more keywords
Phosphoglycerate mutase 5 exacerbates liver ischemia–reperfusion injury by activating mitochondrial fission
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DOI: 10.1038/s41598-024-58748-7
Abstract: Although the death of hepatocytes is a crucial trigger of liver ischemia–reperfusion (I/R) injury, the regulation of liver I/R-induced hepatocyte death is still poorly understood. Phosphoglycerate mutase 5 (PGAM5), a mitochondrial Serine/Threonine protein phosphatase, regulates… read more here.
Keywords: pgam5; liver ischemia; mitochondrial fission; injury ... See more keywords
Negative feedback system to maintain cell ROS homeostasis: KEAP1-PGAM5 complex senses mitochondrially generated ROS to induce mitophagy
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2021.2024702
Abstract: ABSTRACT If cellular reactive oxygen species (ROS) production surpasses the intracellular antioxidant capacity, thus altering the ROS homeostasis, the cell needs to eradicate faulty mitochondria responsible for these excessive ROS. We have shown that even… read more here.
Keywords: pgam5; keap1 pgam5; ros homeostasis; pgam5 complex ... See more keywords
Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging
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DOI: 10.1111/acel.13546
Abstract: Decline in ovarian reserve with aging is associated with reduced fertility and the development of metabolic abnormalities. Once mitochondrial homeostasis is imbalanced, it may lead to poor reproductive cell quality and aging. However, Phosphoglycerate translocase… read more here.
Keywords: pgam5; phosphoglycerate mutase; quality; family member ... See more keywords
Phosphoglycerate mutase 5 promotes necroptosis in trophoblast cells through activation of dynamin-related protein 1 in early-onset preeclampsia.
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DOI: 10.1111/aji.13539
Abstract: OBJECTIVES Placentae from patients with preeclampsia have increased susceptibility tonecroptosis and phosphoglycerate mutase 5 (PGAM5) plays a role in many necrosis pathways.We determined whether PGAM5 promotes necroptosis of trophoblast cells and the underlying mechanisms in… read more here.
Keywords: promotes necroptosis; trophoblast cells; pgam5; phosphoglycerate mutase ... See more keywords
PGAM5 expression and macrophage signatures in non-small cell lung cancer associated with chronic obstructive pulmonary disease (COPD)
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DOI: 10.1186/s12885-018-5140-9
Abstract: BackgroundCOPD patients are at increased risk of developing non-small cell lung carcinoma that has a worse prognosis. Oxidative stress contributes to carcinogenesis and is increased in COPD patients due to mitochondrial dysfunction. We determined whether… read more here.
Keywords: tissue; copd; expression; pgam5 ... See more keywords
PGAM5 cleavage and oligomerization equilibrates mitochondrial dynamics under stress by regulating DRP1 function
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cell Science"
DOI: 10.1242/jcs.263903
Abstract: ABSTRACT Mitochondrial dynamics relies on the function of dynamin family GTPase proteins including mitofusin 1 (MFN1), mitofusin 2 (MFN2) and dynamin-related protein 1 (DRP1; also known as DNM1L). The mitochondrial phosphatase phosphoglycerate mutase 5 (PGAM5)… read more here.
Keywords: cleavage; pgam5; mitochondrial dynamics; stress ... See more keywords
Plasma-derived phosphoglycerate mutase 5 as a biomarker for Parkinson’s disease
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DOI: 10.3389/fnagi.2022.1022274
Abstract: Background We aimed to examine whether plasma-derived phosphoglycerate mutase 5 (PGAM5) can be a biomarker for Parkinson’s disease (PD) diagnosis as well as its association with the severity of motor/non-motor manifestations of PD. Methods We… read more here.
Keywords: pgam5; plasma; parkinson disease; biomarker ... See more keywords
Pgam5 aggravates hyperglycemia-induced myocardial dysfunction through disrupting Phb2-dependent mitochondrial dynamics
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DOI: 10.7150/ijms.92872
Abstract: This study aims to elucidate the roles of Phosphoglycerate Mutase Family Member 5 (Pgam5) and Prohibitin 2 (Phb2) in the context of hyperglycemia-induced myocardial dysfunction, a critical aspect of diabetic cardiomyopathy. The research employed primary… read more here.
Keywords: pgam5; myocardial dysfunction; dysfunction; induced myocardial ... See more keywords