The piggyBac-derived protein 5 (PGBD5) transposes both the closely and the distantly related piggyBac-like elements Tcr-pble and Ifp2.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.166839
Abstract: The vertebrate piggyBac derived transposase 5 (PGBD5) encodes a domesticated transposase, which is active and able to transpose its distantly related piggyBac-like element (pble), Ifp2. This raised the question whether PGBD5 would be more effective… read more here.
Keywords: tcr pble; pble ifp2; pgbd5; piggybac derived ... See more keywords
Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors
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DOI: 10.1126/scitranslmed.aam9078
Abstract: PGBD5 DNA transposase confers therapeutically actionable dependency in solid tumors. Synthetic lethality, pediatric edition Although a variety of therapeutic regimens are available for pediatric solid tumors, they are often ineffective and typically nonspecific. Henssen et… read more here.
Keywords: solid tumors; dna repair; dna; pgbd5 ... See more keywords