HPV E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.159600
Abstract: Therapy with radiation plus cisplatin kills HPV+ oropharyngeal squamous cell carcinomas (OPSCCs) by increasing reactive oxygen species beyond cellular antioxidant capacity. To explore why these standard treatments fail for some patients, we evaluated whether the… read more here.
Keywords: err axis; hpv; antioxidant capacity; pgc err ... See more keywords
Aging, senescence and mitochondria: the PGC-1/ERR axis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-20-0196
Abstract: Aging is a degenerative process that results from the accumulation of cellular and tissue lesions, leading progressively to organ dysfunction and death. Although the biological basis of human aging remains unclear, a large amount of… read more here.
Keywords: senescence mitochondria; mitochondria pgc; pgc err; aging senescence ... See more keywords
PGC-1β and ERRα Promote Glutamine Metabolism and Colorectal Cancer Survival via Transcriptional Upregulation of PCK2
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194879
Abstract: Previous studies have shown that Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1β (PGC-1β) and Estrogen-Related Receptor alpha (ERRα) are over-expressed in colorectal cancer to promote tumor survival. In this study, we show that amino acid motif… read more here.
Keywords: glutamine metabolism; pck2; colorectal cancer; pgc err ... See more keywords