Obesity caused by a high-fat diet regulates the Sirt1/PGC-1α/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older mice
Sign Up to like & getrecommendations! Published in 2019 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2019.1581460
Abstract: ABSTRACT Objectives: To investigate the effects of obesity caused by high-fat diet (HFD) on postoperative cognitive dysfunction (POCD) and expression of the Sirt1/PGC-1α/FNDC5/BDNF pathway in the hippocampus of older mice. Methods: Fifty-six 15-month-old male C57BL/6… read more here.
Keywords: bdnf pathway; fndc5 bdnf; sirt1 pgc; pgc fndc5 ... See more keywords
Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review
Sign Up to like & getrecommendations! Published in 2017 at "F1000Research"
DOI: 10.12688/f1000research.11107.2
Abstract: Background: Exercise may activate a brown adipose-like phenotype in white adipose tissue. The aim of this systematic review was to identify the effects of physical activity on the link between peroxisome proliferator-activated receptor gamma coactivator… read more here.
Keywords: white adipocytes; pgc fndc5; effects physical; irisin ... See more keywords