The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2016.12.037
Abstract: SUMMARY Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. Here, we… read more here.
Keywords: mitochondrial biogenesis; glioblastoma; pgc1 pathway; pgc1 ... See more keywords
Targeting Energy Pathways in Kidney Disease: The Roles of Sirtuins, AMPK, and PGC1α.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.09.037
Abstract: The kidney has extraordinary metabolic demands to sustain the active transport of solutes that is critical to renal filtration and clearance. Mitochondrial health is vital to meet those demands and maintain renal fitness. Decades of… read more here.
Keywords: mitochondrial health; pgc1; disease; targeting energy ... See more keywords
TLR4 signaling modulation of PGC1-α mediated mitochondrial biogenesis in the LPS-Chronic mild stress model: Effect of fluoxetine and pentoxiyfylline.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116869
Abstract: AIM The addition of repeated lipopolysaccharide (LPS) to chronic mild stress was recently proposed in our lab as an alternative model of depression, highlighting the possible interaction between stress and immune-inflammatory pathways in predisposing depression.… read more here.
Keywords: pgc1; model; stress; tlr4 signaling ... See more keywords
The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1α inhibition
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101226
Abstract: Objective MicroRNAs (miRNA) are known to regulate the expression of genes involved in several physiological processes including metabolism, mitochondrial biogenesis, proliferation, differentiation, and cell death. Methods Using “in silico” analyses, we identified 219 unique miRNAs… read more here.
Keywords: skeletal muscle; snark; muscle; pgc1 ... See more keywords
PGC1α regulates mitochondrial oxidative phosphorylation involved in cisplatin resistance in ovarian cells via nucleo-mitochondrial transcriptional feedback.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112369
Abstract: Mitochondria play an important role in effective cell energy production and cell survival under stress conditions, such as treatment with chemotherapeutic drugs. Mitochondrial biogenesis is increased in ovarian cancer tissues, which is accompanied by alteration… read more here.
Keywords: pgc1; mitochondrial oxidative; resistance; cell ... See more keywords
Full-length-transcriptomic analysis in mice and human heart using Single-Molecule Real-time Sequencing (SMRT) identified 15 novel isoforms and a novel promoter region of PGC1-alpha
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3582
Abstract: Alternative splicing is a process by which exons within a pre-mRNA are joined or skipped, resulting in isoforms being encoded by a single gene. Alternative Splicing affecting transcription factors may have substantial impact on cellular… read more here.
Keywords: human heart; heart; full length; pgc1 ... See more keywords
Induction of beige‐like adipocyte markers and functions in 3T3‐L1 cells by Clk1 and PKCβII inhibitory molecules
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17345
Abstract: Excessive dietary intake of fat results in its storage in white adipose tissue (WAT). Energy expenditure through lipid oxidation occurs in brown adipose tissue (BAT). Certain WAT depots can undergo a change termed beiging where… read more here.
Keywords: inhibition; pgc1; clk1; clk1 pkc ... See more keywords
CD38 deficiency promotes skeletal muscle and brown adipose tissue energy expenditure through activating NAD+-Sirt1-PGC1α signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2022-0454
Abstract: Obesity is a metabolic syndrome characterized by abnormal lipid deposition and energy imbalance. CD38 is a single chain transmembrane glycoprotein widely expressed in a variety of cell types. The roles of skeletal muscle and brown… read more here.
Keywords: pgc1; energy; cd38 deficiency; muscle brown ... See more keywords
PGC1α suppresses prostate cancer cell invasion through ERRα transcriptional control.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-1231
Abstract: The peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1α) is a prostate tumor suppressor that controls the balance between anabolism and catabolism. PGC1A downregulation in prostate cancer is causally associated with the development of metastasis.… read more here.
Keywords: pgc1; prostate cancer; err; cancer cell ... See more keywords
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity.
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/circresaha.119.315529
Abstract: RATIONALE PGC1α represents an attractive target interfering bioenergetics and mitochondrial homeostasis, yet multiple attempts have failed to upregulate PGC1α expression as a therapy, for instance, causing cardiomyopathy. OBJECTIVE To determine whether a fine-tuning of PGC1α… read more here.
Keywords: expression; mice; pgc1 expression; fine tuning ... See more keywords
Dual PPARα/γ activation inhibitsSIRT1-PGC1α axis and causes cardiac dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "JCI Insight"
DOI: 10.1172/jci.insight.129556
Abstract: Dual peroxisome proliferator-activated receptor (PPAR)α/γ agonists that were developed to target hyperlipidemia and hyperglycemia in type 2 diabetes patients, caused cardiac dysfunction or other adverse effects. We studied the mechanisms that underlie the cardiotoxic effects… read more here.
Keywords: activation; mice; pgc1; cardiac dysfunction ... See more keywords