The wound-healing effect of 7,3′,4′-trimethoxyflavone through increased levels of prostaglandin E2 by 15-hydroxyprostaglandin dehydrogenase inhibition
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DOI: 10.1007/s10529-017-2386-2
Abstract: ObjectiveTo find an inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that rapidly metabolises Prostaglandin E2 (PGE2) as a mediator of wound healing, we examined seven flavonoids for this role.Results7,3′,4′-Trimethoxyflavone (TMF) had the lowest IC50 value of 0.34 µM… read more here.
Keywords: wound healing; healing effect; hydroxyprostaglandin dehydrogenase; pgdh ... See more keywords
Tumour suppressor 15-hydroxyprostaglandin dehydrogenase induces differentiation in colon cancer via GLI1 inhibition
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DOI: 10.1038/s41389-020-00256-0
Abstract: Inflammation is an established risk factor for colorectal cancer. We and others have shown that colorectal cancer patients with elevated cysteinyl leukotriene receptor 2 (CysLT2R) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) levels exhibit good prognoses. However, both… read more here.
Keywords: gli1; pgdh; colorectal cancer; colon cancer ... See more keywords
Association between COX‐2 and 15‐PGDH polymorphisms and SLE susceptibility
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DOI: 10.1111/1756-185x.13808
Abstract: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Prostaglandins E2 (PGE2), the product of the cyclo‐oxygenase 2 (COX‐2) enzyme, has critical roles in the etiology of autoimmune diseases. PGE2 level is controlled by… read more here.
Keywords: pgdh polymorphisms; cox; cox pgdh; polymorphisms sle ... See more keywords
Expression of COX-2 and 15-PGDH in adenomas removed during pretreatment colonoscopy to predict chemopreventive efficacy of the selective COX-2 inhibitor, celecoxib.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.4_suppl.524
Abstract: 524Background: The APC trial showed that patients at high risk for colorectal adenoma development experienced a 33-45% reduction in post-polypectomy adenoma detection when treated with the selective cyclooxygenase-2 (cox-2) inhibitor, celecoxib. Unfortunately, this study also… read more here.
Keywords: inhibitor celecoxib; pgdh; cox; expression ... See more keywords
Identification and Biochemical Characterization of the Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase in Marchantia polymorpha
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DOI: 10.3389/fpls.2018.00956
Abstract: L-serine is an important molecule in all living organisms, and thus its biosynthesis is considered to be regulated according to demand. 3-Phosphoglycerate dehydrogenase (PGDH), the first committed enzyme of the phosphorylated pathway of L-serine biosynthesis,… read more here.
Keywords: pgdh; phosphoglycerate dehydrogenase; marchantia polymorpha; serine ... See more keywords
Helicobacter pylori modulates cyclooxygenase-2 and 15-hydroxy prostaglandin dehydrogenase in gastric cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.6843
Abstract: Persistent infection with Helicobacter pylori may contribute to the carcinogenesis of gastric cancer through modulating local prostaglandin E2 (PGE2) levels. Cyclooxygenase-2 (COX-2) and 15-hydroxy prostaglandin dehydrogenase (15-PGDH) are two key enzymes that regulate PGE2 synthesis… read more here.
Keywords: prostaglandin; gastric cancer; pgdh; infection ... See more keywords