Polysubstituted Pyrimidines as Potent Inhibitors of Prostaglandin E2 Production: Increasing Aqueous Solubility
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100263
Abstract: Water solubility is one of the key features of potential therapeutic agents. In order to enhance the low water solubility of the parent 5‐butyl‐4‐(4‐methoxyphenyl)‐6‐phenylpyrimidin‐2‐amine, a potent inhibitor of prostaglandin E2 (PGE2) production, we synthesized and… read more here.
Keywords: production; water solubility; solubility; parent ... See more keywords
miR-122 and the WNT/β-catenin pathway inhibit effects of both interleukin-1β and tumor necrosis factor-α in articular chondrocytes in vitro.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30244
Abstract: Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and WNT/β-catenin signaling cause dysregulation of rat primary articular chondrocytes (rArCs), resulting in cartilage extracellular matrix destruction and osteoarthritis (OA) progression. microRNA (miR) miR-122 represses these effects whereas miR-451… read more here.
Keywords: mmp pge2; mir 451; wnt catenin; pge2 production ... See more keywords
TGF-β1 stimulates cyclooxygenase-2 expression and PGE2 production of human dental pulp cells: Role of ALK5/Smad2 and MEK/ERK signal transduction pathways.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Formosan Medical Association = Taiwan yi zhi"
DOI: 10.1016/j.jfma.2017.07.008
Abstract: BACKGROUND/PURPOSES TGF-β1 is an important growth factor that may influence the odontoblast differentiation and matrix deposition in the reactionary/reparative dentinogenesis to dental caries or other tooth injuries. TGF-β1 exerts its effects through various signaling pathways,… read more here.
Keywords: tgf; pulp cells; dental pulp; pge2 production ... See more keywords
P-240 CD4+ T Cell-intrinsic PGE2 Production Alters Their Colitogenic and Suppressive Potential
Sign Up to like & getrecommendations! Published in 2017 at "Inflammatory Bowel Diseases"
DOI: 10.1097/01.mib.0000512755.68482.2e
Abstract: Background: The integration of inflammatory signals is paramount in controlling the intensity and duration of immune responses. Eicosanoids, particularly prostaglandin E2 (PGE2), are critical molecules in the initiation and resolution of inflammation and in the… read more here.
Keywords: cd4 cd25; pge2 production; pge2; cell ... See more keywords
Factors affecting PGE2 production in seaweed Gracilaria tenuistipitata
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Food and Drug Analysis"
DOI: 10.38212/2224-6614.2358
Abstract: Gracilaria tenuistipitata is an edible red alga and can be utilized as feed for small abalone and foodstuff (ex. agar extract). It is the major species of Gracilaria that is commonly cultivated and consumed in… read more here.
Keywords: gracilaria tenuistipitata; production seaweed; pge2 production; production ... See more keywords